Adapalene EP Impurity A CAS 932033-58-4
| CAS No. | 932033-58-4 |
| Molecular Formula | C22H14O4 |
| Molecular Weight | 342.34 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Adapalene EP Impurity A.
CATO supplies Adapalene EP Impurity A (CAS 932033-58-4), a pharmacopoeial impurity reference standard (molecular formula C22H14O4, MW 342.34 g/mol) used for the identification and quantification of trace impurities in APIs.
Adapalene EP Impurity A (C22H14O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Adapalene EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H14O4 |
| Molecular Weight | 342.34 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1987 |
Related Adapalene Standards
- Adapalene Impurity 11 (CAS CATO-C4X-180911)
- Adapalene impurity 20 (CAS CATO-C4X-180920)
- Adapalene Impurity 14 (CAS 1036766-56-9)
- Adapalene Impurity 10 (CAS 161912-38-5)
- Adapalene Impurity 9 (CAS 132292-17-2)
- Adapalene Impurity 12 (CAS 1063712-23-1)
- Adapalene Impurity 13 (CAS 106685-43-2)
- Adapalene (CAS 106685-40-9)
Recommended Standards
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- 1-((2-Chloro-4-nitrophenyl)amino)-1-oxopropan-2-yl 2-(methylthio)nicotinate (CAS 502595-88-2)
- D-Tyr1-Tirzepatide (CAS CATO-CPTD788928)
Why CATO?
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