N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide CAS 337498-47-2
| CAS No. | 337498-47-2 |
| Molecular Formula | C17H13ClN4O5S |
| Molecular Weight | 420.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide.
N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide (CAS 337498-47-2) is a high-purity analytical reference standard with the molecular formula C17H13ClN4O5S and a molecular weight of 420.83 g/mol.
N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide (C17H13ClN4O5S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H13ClN4O5S |
| Molecular Weight | 420.83 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related N Standards
- 1-(2-Chloro-4-nitrophenyl)-N-(phenylsulfamoyl)-1H-pyrrole-2-carboxamide (CAS 383147-37-3)
- 2-((4-Chloro-N-(3-(trifluoromethyl)phenyl)phenyl)sulfonamido)-N,N-dimethylacetamide (CAS 337922-20-0)
- N-(3-Chloro-2,4-difluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine (CAS 848491-25-8)
- (E)-4-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)benzaldehyde O-(3-methoxybenzyl) oxime (CAS 1092343-78-6)
- 2-Chloro-5-nitro-N-(4-(quinoxalin-2-yloxy)phenyl)benzamide (CAS 647853-12-1)
- 3-[(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}phenoxy)methyl]benzamide (CAS 339020-28-9)
- 4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methyl}phenyl N-(4-methylphenyl)carbamate (CAS 339020-34-7)
- 5-Chloro-N-methyl-2-oxo-N-phenyl-1-(4-(trifluoromethyl)benzyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-90-5)
Recommended Standards
- 2-((5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-methoxy-4-nitrophenyl)acetamide (CAS 332160-29-9)
- 3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid (CAS 1224102-50-4)
- 1,4,6,7,8,9-Hexachlorodibenzo[b,e][1,4]dioxine-2,3-dione (CAS 65005-72-3)
- 2-[6-Amino-4-(2-chloro-6-fluorophenyl)-5-cyano-2-methyl-4H-pyran-3-carbonyloxy]ethyl 2-methylprop-2-enoate (CAS 939888-87-6)
- 2-(Difluoromethyl)-6-hydroxypyridine-3-methanol (CAS 1806777-42-3)
- 9-(2,4-Dichlorophenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a]1,8-naphthyridine (CAS 338773-44-7)
- Ethyl 2-{2-[({[(3-chlorobenzyl)oxy]imino}methyl)amino]-1,3-thiazol-4-yl}benzenecarboxylate (CAS 250713-84-9)
- 3-(1-Aminocyclopropyl)propanoic acid (CAS 126822-30-8)
- 6,7-Dimethylquinolin-4-ol (CAS 185437-33-6)
- 1-(1-(4-Aminophenyl)piperidin-4-yl)ethan-1-ol (CAS 1694083-82-3)
- Glutamic acid impurity 6 (CAS 1308957-12-1)
- Ethyl (3R,4S)-1-benzyl-4-(3,4-dimethoxyphenyl)pyrrolidine-3-carboxylate (CAS 2329045-07-8)
- 3-(Methylsulfonyl)-1H-pyrrole (CAS 82511-59-9)
- (Cys2)-Neuropeptide Y-8-aminooctanoyl-(D-Cys27)-Neuropeptide Y (25-32) (H-3298.0500) (CAS 128806-04-2)
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