3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid CAS 1224102-50-4
| CAS No. | 1224102-50-4 |
| Molecular Formula | C21H19ClF2N2O3 |
| Molecular Weight | 420.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid (CAS 1224102-50-4) is a high-purity analytical reference standard with the molecular formula C21H19ClF2N2O3 and a molecular weight of 420.84 g/mol.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 3-(4-((1-(4-Chlorophenyl)-3-methyl-1H-pyrazol-5-yl)methoxy)-3,5-difluorophenyl)-2-methylpropanoic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 420.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H19ClF2N2O3 |
| Molecular Weight | 420.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 2-((5-(2-Chlorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(2-methoxy-4-nitrophenyl)acetamide (CAS 332160-29-9)
- 2-(4-Chlorophenyl)-7-ethoxy-5-(4-nitrophenyl)-3H-benzo[e][1,2,4]triazepine (CAS 444159-02-8)
- 2-(4-Chlorophenyl)-N-((dimethylamino)methylene)-2-(3-(trifluoromethyl)quinoxalin-2-yl)acetamide (CAS 338412-27-4)
- (4-Chlorophenyl)(3-(1-((2-fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-1H-pyrazol-1-yl)methanone (CAS 477709-14-1)
- (5Z)-5-{[(2-chlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 339096-93-4)
- (5Z)-5-{[(3-chlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 339096-94-5)
- (5Z)-5-{[(4-chlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 338793-35-4)
- 2-[1-(4-Chlorophenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-2-oxo-N-[4-(trifluoromethyl)phenyl]acetamide (CAS 866152-59-2)
Recommended Standards
- N-(4-chloro-3-nitrophenyl)-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)thio)acetamide (CAS 337498-47-2)
- 1,4,6,7,8,9-Hexachlorodibenzo[b,e][1,4]dioxine-2,3-dione (CAS 65005-72-3)
- N-(3-Chloro-2,4-difluorophenyl)-7-methoxy-6-(piperidin-4-yloxy)quinazolin-4-amine (CAS 848491-25-8)
- 2-((4-Chloro-N-(3-(trifluoromethyl)phenyl)phenyl)sulfonamido)-N,N-dimethylacetamide (CAS 337922-20-0)
- 1-Cyclopentyl-2-(pyridin-2-yl)ethan-1-one (CAS 115045-66-4)
- 1-(3,4-Dihydro-2H-pyrrol-5-yl)propan-1-one (CAS 133447-37-7)
- Methyl 1,4-dichlorophthalazine-6-carboxylate (CAS 1416713-80-8)
- Aprepitant Impurity 18 (CAS CATO-C4X-114118)
- 1-(4-Chlorophenethyl)-5-methoxy-3,4-dimethyl-1,5-dihydro-2H-pyrrol-2-one (CAS 731831-70-2)
- 1-(4-Mercaptobenzo[d]oxazol-2-yl)ethanone (CAS 1803742-13-3)
- 6-Bromo-3-(4-bromobenzyl)quinazolin-4(3H)-one (CAS 302913-23-1)
- 1-(tert-butylsulfanyl)-2-fluoro-4-nitrobenzene (CAS 1864061-71-1)
- 4-(P-tolyl)-1H-imidazole-1,2-diamine (CAS 15965-80-7)
- Cholecystokinin Octapeptide (desulfated) (H-2070.0005) (CAS 198483-36-2)
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