Labetalol EP Impurity B HCl CAS 33778-93-7
| CAS No. | 33778-93-7 |
| Molecular Formula | C20H25NO4 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Labetalol EP Impurity B HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Labetalol EP Impurity B HCl (CAS 33778-93-7), a pharmacopoeial impurity reference standard (molecular formula C20H25NO4HCl, MW 379.88 g/mol) used for the identification and quantification of trace impurities in APIs.
Labetalol EP Impurity B HCl (C20H25NO4HCl) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H25NO4 HCl |
| Molecular Weight | 379.88 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1966 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Labetalol Standards
- Labetalol Impurity 29 (CAS 119021-71-5)
- Labetalol EP Impurity A (CAS 1391051-99-2)
- Labetalol Impurity 9 (CAS 22374-89-6)
- Labetalol EP Impurity C HCl (CAS 2386661-13-6)
- Labetalol-d5 HCl (CAS 2713514-78-2)
- Labetalol Impurity 23 (CAS 2724509-52-6)
- Labetalol Impurity 56 (CAS 2731858-23-2)
- Labetalol EP Impurity D HCl (CAS 32780-65-7)
Recommended Standards
- Domperidone Impurity 28 (CAS CATO-C4X-142028)
- Amphotericin B EP Impurity A (CAS 1405-32-9)
- Saxagliptin Impurity 46 (CAS 361440-67-7)
- 2H-Indeno[2,1-c]pyridazine-3,9-dione (CAS 100595-21-9)
- (R)-(3-Chloro-2-hydroxypropyl)phosphonic acid (CAS 221627-94-7)
- (R)-2-Amino-5-methoxytetralin hydrochloride, 97% (CAS 58349-15-8)
- 4,6-Dihydroxy-5-methylpyrimidine (CAS 63447-38-1)
- 1-(2-Pyridyl)imidazole-5-carboxylic Acid (CAS 1779128-15-2)
- 2-(Pyrazin-2-yl)thiazole-5-carbaldehyde (CAS 1250594-09-2)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com