3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-(morpholin-4-yl)propan-1-one CAS 337920-45-3
| CAS No. | 337920-45-3 |
| Molecular Formula | C13H14ClF3N2O2 |
| Molecular Weight | 322.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-(morpholin-4-yl)propan-1-one (CAS 337920-45-3), molecular formula C13H14ClF3N2O2 and molecular weight 322.71 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-(morpholin-4-yl)propan-1-one (C13H14ClF3N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 322.71 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H14ClF3N2O2 |
| Molecular Weight | 322.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-hydroxypiperidine-4-carboximidamide (CAS 1221794-66-6)
- 4-Chloro-2-(difluoro(4-fluorophenyl)methyl)-7-methylquinazoline (CAS 1241915-17-2)
- 1-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)methyl)piperidine-4-carboxylic acid (CAS 1311279-30-7)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperidine-4-carbohydrazide (CAS 321430-54-0)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperidin-4-yl acetate (CAS 321430-31-3)
- 1-[5-Chloro-2-nitro-4-(trifluoromethyl)phenyl]azepane (CAS 646456-34-0)
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Recommended Standards
- 3-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-4-methylquinoline (CAS 882747-53-7)
- 5-(4-Chlorophenyl)-1-phenyl-3-(trifluoromethyl)-1H-pyrazole (CAS 586333-28-0)
- 2-Chloro-n-[2-(morpholin-4-yl)-5-(trifluoromethyl)phenyl]acetamide (CAS 379255-35-3)
- Ethyl 5-(chloromethyl)-1-[4-(1H-pyrrol-1-yl)-1,2,5-oxadiazol-3-yl]-1H-1,2,3-triazole-4-carboxylate (CAS 681851-71-8)
- Propyl 2-chloroacetate (CAS 5396-24-7)
- 1-(2-Phenylsulfanyl-phenyl)-pyrrole-2,5-dione (CAS 568551-29-1)
- 2-(Methylamino)-3-nitrobenzoic acid (CAS 124341-38-4)
- 2-(2,6-Dibromo-5-(difluoromethyl)pyridin-3-yl)acetic acid (CAS 1805330-48-6)
- 1-(4-(2-Hydroxy-2-methylpropyl)piperazin-1-yl)-2-methoxyethan-1-one (CAS 1311970-42-9)
- (6-Bromopyridin-3-yl)(piperidin-1-yl)methanone (CAS 1199260-11-1)
- 2-(bromomethyl)-4-methylpentanenitrile (CAS 1273849-47-0)
- (3-(5-Methyl-1,3,4-oxadiazol-2-yl)phenyl)boronic acid (CAS 913836-04-1)
- 6-(2,5-Dimethoxyphenyl)-3-(piperidin-4-yl)-[1,2,4]triazolo[4,3-b]pyridazine (CAS 1706463-90-2)
- Semaglutide impurity 39 (CAS CATO-C4X-222639)
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