3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methoxy}-1-[(1Z)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]urea CAS 338396-80-8
| CAS No. | 338396-80-8 |
| Molecular Formula | C16H12Cl3F3N4O3 |
| Molecular Weight | 471.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 471.65 g/mol gives 3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methoxy}-1-[(1Z)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]urea distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methoxy}-1-[(1Z)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]urea (CAS 338396-80-8), molecular formula C16H12Cl3F3N4O3 and molecular weight 471.65 g/mol, is a CATO reference standard with documented purity and traceability.
3-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]methoxy}-1-[(1Z)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]urea (C16H12Cl3F3N4O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H12Cl3F3N4O3 |
| Molecular Weight | 471.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related chloro Standards
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Recommended Standards
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- Buprenorphine-D4 (CAS 136781-89-0)
- (4-Methyl-piperidin-4-yl)-acetic acid hydrochloride (CAS 1373223-36-9)
- 2-(Prop-2-yn-1-ylsulfanyl)ethan-1-amine (CAS 75606-28-9)
- 4-(4-Chlorophenyl)-N-(3-fluorophenyl)-1,2,3,6-tetrahydropyridine-1-carboxamide (CAS 866151-73-7)
- 1-(2-Methyl-5-phenylthiophen-3-yl)ethanone (CAS 40932-63-6)
- 5-Amino-N-methyl-3-oxoisoxazole-2(3H)-carboxamide (CAS 27066-61-1)
- 6-((tert-Butoxycarbonyl)amino)spiro[3.3]heptane-2-carboxylic acid (CAS 1087798-38-6)
- 4-bromoisoquinolin-3-amine (CAS 10321-49-0)
- 3-(Chlorodifluoromethyl)-6-(1-ethyl-3-methyl-1h-pyrazol-4-yl)-7h-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine (CAS 1003993-47-2)
- 3-Bromo-4-methyl-5-nitro-2-pyridinone (CAS 1049706-72-0)
- Mast Cell Degranulating Peptide (CAS 83856-13-7)
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