(8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,8-diazaspiro[4.5]Decan-4-yl)(phenyl)methanone CAS 338397-32-3
| CAS No. | 338397-32-3 |
| Molecular Formula | C20H19ClF3N3O2 |
| Molecular Weight | 425.83 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,8-diazaspiro[4.5]Decan-4-yl)(phenyl)methanone is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,8-diazaspiro[4.5]Decan-4-yl)(phenyl)methanone (CAS 338397-32-3) is a high-purity analytical reference standard with the molecular formula C20H19ClF3N3O2 and a molecular weight of 425.83 g/mol.
The molecular framework of (8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,8-diazaspiro[4.5]Decan-4-yl)(phenyl)methanone (C20H19ClF3N3O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures (8-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1-oxa-4,8-diazaspiro[4.5]Decan-4-yl)(phenyl)methanone under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19ClF3N3O2 |
| Molecular Weight | 425.83 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 3-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[(1E)-{[2-(morpholin-4-yl)-2-oxoethoxy]amino}methylidene]thiourea (CAS 477885-61-3)
- 2-(4-Chloro-2-methylphenoxy)-1-(1-(4-(trifluoromethoxy)phenyl)-1H-1,2,3-triazol-4-yl)propan-1-one (CAS 478248-71-4)
- 3-Chloro-2-{[7-(4-fluorophenyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl]sulfanyl}-5-(trifluoromethyl)pyridine (CAS 338775-07-8)
- (2-(4-Chloro-2-methylphenoxy)pyridin-3-yl)(4-(2-fluorophenyl)piperazin-1-yl)methanone (CAS 497060-65-8)
- 1-(3-Chloro-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl)-N-(pyridin-2-ylmethyl)methanesulfonamide (CAS 1001917-35-6)
- N-(3-Chloro-4-methoxyphenyl)-2-{4-oxo-7-phenyl-3H,4H-thieno[3,2-d]pyrimidin-3-yl}acetamide (CAS 1105235-07-1)
- N-(4-chloro-2-methylphenyl)-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-2-carboxamide (CAS 477872-23-4)
- 1-(4-Chloro-2-methylphenyl)-3-(1-((4-fluorophenyl)sulfonyl)piperidin-4-yl)urea (CAS 672950-46-8)
Recommended Standards
- 2,4-Dichloro-1-{[({2-[(4-chlorophenyl)sulfanyl]phenyl}methyl)sulfanyl]methyl}benzene (CAS 337923-79-2)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(4-chloro-3-fluorophenyl)acetic acid (CAS 2349702-20-9)
- 2,2,2-Trifluoro-N-(2,4,6-tribromophenyl)acetamide (CAS 68545-90-4)
- 2,4-Dimethyl 5-(3-chlorobenzamido)-3-(2-methoxy-2-oxoethyl)thiophene-2,4-dicarboxylate (CAS 338393-17-2)
- 1-(Bromomethyl)-3-nitro-5-(trifluoromethyl)benzene (CAS 180146-67-2)
- 2-Hydroxyquinoline-4-carbohydrazide (CAS 41874-24-2)
- 2-Chloro-4-methyl-3-nitropyridine (CAS 23056-39-5)
- 5-((4-Ethylphenyl)amino)-6-methyl-1,2,4-triazin-3-ol (CAS 526187-11-1)
- Fruquintinib Impurity 2 (CAS 2357686-21-4)
- N-((1,3-Dimethyl-1H-pyrazol-5-yl)methyl)-1-isopropyl-4-methyl-1H-pyrazol-3-amine hydrochloride (CAS 1855938-73-6)
- Flunixin D3 (methyl D3) (CAS 1015856-60-6)
- 4-Amino-5-bromo-1-(tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 18002-36-3)
- N-Isopropylpiperidine-4-carboxamide hydrochloride (CAS 1019851-92-3)
- Des-Pro31-Tirzepatide (CAS CATO-CPTD788943)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com