1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-sulfonamide CAS 338406-72-7
| CAS No. | 338406-72-7 |
| Molecular Formula | C17H12Cl2F3N3O2S |
| Molecular Weight | 450.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-sulfonamide is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-sulfonamide (CAS 338406-72-7) is a high-purity analytical reference standard with the molecular formula C17H12Cl2F3N3O2S and a molecular weight of 450.26 g/mol.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-sulfonamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 450.26 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N-[(4-chlorophenyl)methyl]-1H-pyrrole-2-sulfonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H12Cl2F3N3O2S |
| Molecular Weight | 450.26 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 1-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl](methyl)amino}-3-[(4-chlorophenyl)sulfanyl]pyrrolidine-2,5-dione (CAS 339110-57-5)
- 3-(2-chloro-6-fluorophenyl)-4-[4-(4-chloro-3-nitrophenyl)-1,3-thiazol-2-yl]-5-methylisoxazole (CAS 287176-95-8)
- 1-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-((4-chlorophenyl)thio)ethan-1-one (CAS 260442-99-7)
- 4-Chloro-N-(2-((4-chloro-3-nitrophenyl)amino)-2-oxoethyl)-N-cyclohexylbenzamide (CAS 332156-36-2)
- N-(2-chloro-6-((4-isopropyl-1-methyl-7-oxabicyclo[2.2.1]heptan-2-yl)oxy)benzyl)benzenesulfonamide (CAS 1005085-57-3)
- 4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2,2-diphenyl-butyric acid (CAS 82103-70-6)
- 2-Chloro-N-(4-(((4-fluorophenyl)thio)methyl)phenyl)-4-(methylsulfonyl)benzamide (CAS 338398-82-6)
- 3-Chloro-N-(4-(n-(thiazol-2-yl)sulfamoyl)phenyl)benzo[b]thiophene-2-carboxamide (CAS 215778-07-7)
Recommended Standards
- 2,5-Bis(bromomethyl)-1-methoxy-4-(3′,7′-dimethyloctyloxy)benzene (CAS 287919-00-0)
- N-(3-(3,4-dichlorophenyl)imidazo[1,2-a]pyridin-8-yl)-3-(trifluoromethyl)benzamide (CAS 338415-25-1)
- 2,4-bis(trifluoromethyl)-9-[3-(trifluoromethyl)phenyl][1,2,4]triazolo[4,3-a][1,8]naphthyridine (CAS 338962-21-3)
- 6,8-Dibromo-2-(2-((tert-butyldimethylsilyl)oxy)ethyl)-5-methyl-[1,2,4]triazolo[1,5-a]pyrazine (CAS 2428557-56-4)
- 7-Azaindol-2-ol (CAS 1261802-66-7)
- 4-tert-Butyl-5-methyl-1,3-thiazol-2-amine (CAS 149488-88-0)
- 4-Pivalamidobutanoic Acid (CAS 69542-93-4)
- tert-Butyl (2S)-4,4-diethoxy-2-(hydroxymethyl)-piperidine-1-carboxylate (CAS 1212360-70-7)
- N-(3,4-Dichlorobenzyl)-2H-tetrazol-5-amine (CAS 162960-77-2)
- 1-(4-Chlorophenyl)pentane-1,3-dione (CAS 26732-06-9)
- 3-(3-Bromophenyl)-5-(furan-2-ylmethylene)-4-thioxothiazolidin-2-one (CAS 306322-32-7)
- Hydroxy-PEG3-2-methylacrylate (CAS 2351-42-0)
- 3-(Chloromethyl)-1-methyl-5-(thiophen-2-yl)-1H-pyrazole (CAS 876316-61-9)
- [y-Glu15]-Semaglutide Impurity 134 (CAS CATO-C4X-2226134)
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