N-(4-chlorobenzyl)-2-nitro-4-(trifluoromethyl)benzamide CAS 338408-52-9
| CAS No. | 338408-52-9 |
| Molecular Formula | C15H10ClF3N2O3 |
| Molecular Weight | 358.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
N-(4-chlorobenzyl)-2-nitro-4-(trifluoromethyl)benzamide (CAS 338408-52-9) is a high-purity analytical reference standard with the molecular formula C15H10ClF3N2O3 and a molecular weight of 358.70 g/mol.
N-(4-chlorobenzyl)-2-nitro-4-(trifluoromethyl)benzamide (C15H10ClF3N2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H10ClF3N2O3 |
| Molecular Weight | 358.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related N Standards
- N-(2-Chlorobenzyl)-4-(2,4-dichlorophenoxy)-1-butanamine (CAS 1040684-21-6)
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Recommended Standards
- 2-chloro-N-[imino(pyridin-4-yl)methyl]-6-(2,2,2-trifluoroethoxy)isonicotinamide (CAS 287979-32-2)
- N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide (CAS 266337-53-5)
- 2-[(E)-(4-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)methylidene]-1-hydrazinecarboxamide (CAS 1025634-84-7)
- NS3694 (CAS 426834-38-0)
- Methylmalonic acid (dipotassium) (CAS 77939-79-8)
- 4227-95-6 iodomethane-(13)C stab.,~99 (atom % 13C) (CAS 4227-95-6)
- (5S)-5,6-Dihydro-6,6-dimethyl-5-phenyl-2H-1,4-oxazin-2-one (CAS 723262-95-1)
- 1-(4-Chlorophenyl)-5-methylpyrrolidine-2,4-dione (CAS 114462-95-2)
- 1-Benzyl-4-(hydroxydiphenylmethyl)quinuclidin-1-ium bromide (CAS 869113-10-0)
- 2-Fluoro-3-nitrobenzoyl chloride (CAS 1214341-16-8)
- cis-4-Aminomethyl-3-hydroxypiperidine (CAS 1419101-21-5)
- 2-(3-Chlorophenoxy)-5-(trifluoromethyl)aniline (CAS 946773-26-8)
- N-(4-Aminophenyl)-2-isobutoxybenzamide (CAS 1020054-00-5)
- D-Phe6-Tirzepatide (CAS CATO-CPTD788925)
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