N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide CAS 266337-53-5
| CAS No. | 266337-53-5 |
| Molecular Formula | C14H10ClF3N4O2 |
| Molecular Weight | 358.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide.
CATO supplies N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide (CAS 266337-53-5), a certified reference material (molecular formula C14H10ClF3N4O2, MW 358.70 g/mol) for analytical method development and quality control.
The molecular framework of N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide (C14H10ClF3N4O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N'1-[(2-chloro-6-methylpyrimidin-4-yl)carbonyl]-3-(trifluoromethyl)benzene-1-carbohydrazide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H10ClF3N4O2 |
| Molecular Weight | 358.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related N Standards
- 2-[(E)-(4-{[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]oxy}phenyl)methylidene]-1-hydrazinecarboxamide (CAS 1025634-84-7)
- 2-chloro-N-[imino(pyridin-4-yl)methyl]-6-(2,2,2-trifluoroethoxy)isonicotinamide (CAS 287979-32-2)
- 3-Chloro-5-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (CAS 2761197-19-5)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)difluoromethyl)thiazole-4-carboxylic acid (CAS 1823184-07-1)
- 5-Chloro-2-(4-chloro-3,5-dimethyl-1H-pyrazol-1-yl)-4-(4-chlorophenyl)-1,3-thiazole (CAS 956187-27-2)
- 2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)thio)-5-(pyridin-3-yl)-1,3,4-oxadiazole (CAS 400082-32-8)
- N-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}ethyl)-2-methylbenzamide (CAS 1407543-80-9)
- 3-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-pyrazole (CAS 1690341-76-4)
Recommended Standards
- N-(4-chlorobenzyl)-2-nitro-4-(trifluoromethyl)benzamide (CAS 338408-52-9)
- NS3694 (CAS 426834-38-0)
- Triflumuron (CAS 64628-44-0)
- 2-Chlorobenzene-1,3,5-trisulfonyl trifluoride (CAS 1342799-69-2)
- 3-Allyl-5-aminobenzo[d]oxazol-2(3h)-one (CAS 1018617-68-9)
- 3-(4-(3-(4-(2,3-Dihydrobenzo[b][1,4]dioxine-6-carbonyl)piperidin-1-yl)-3-oxopropyl)-3,5-dimethyl-1H-pyrazol-1-yl)propanenitrile (CAS 1197728-20-3)
- Methyl 3-((2,4-difluorophenoxy)methyl)benzoate (CAS 1259143-67-3)
- 2-Methyl-4-(p-tolyl)phthalazin-1(2H)-one (CAS 21332-68-3)
- 3-Bromo-2-(piperidin-1-yl)-5-(trifluoromethyl)pyridine (CAS 1437485-40-9)
- 4-Chloro-1-heptyl-1h-pyrazol-3-amine (CAS 1477807-49-0)
- (1-(Tetrahydro-2H-thiopyran-4-yl)pyrrolidin-3-yl)methanol (CAS 1598831-73-2)
- 2-Fluoro-6-nitro-N-(piperidin-4-ylmethyl)aniline hydrochloride (CAS 1286263-43-1)
- 5-(2-Chloro-5-nitrophenyl)-3-(2-methoxyphenyl)-1,2,4-oxadiazole (CAS 1119395-82-2)
- [Nva12]-Tirzepatide (CAS CATO-C4X-324042)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com