1-[(3,4-Dichlorophenyl)methyl]-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione CAS 338418-94-3
| CAS No. | 338418-94-3 |
| Molecular Formula | C23H16Cl2N2O2S |
| Molecular Weight | 455.36 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies 1-[(3,4-Dichlorophenyl)methyl]-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 338418-94-3), a certified reference material (molecular formula C23H16Cl2N2O2S, MW 455.36 g/mol) for analytical method development and quality control.
1-[(3,4-Dichlorophenyl)methyl]-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (C23H16Cl2N2O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C23H16Cl2N2O2S |
| Molecular Weight | 455.36 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 16.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Dichlorophenyl Standards
- 1-(3,4-Dichlorophenyl)-2-((5-(pyridin-4-yl)-4-(p-tolyl)-4H-1,2,4-triazol-3-yl)thio)ethanone (CAS 575469-40-8)
- 1-[(2,4-Dichlorophenyl)methyl]-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 338418-91-0)
- 1-[(2,6-Dichlorophenyl)methyl]-3'-phenyl-1,2-dihydrospiro[indole-3,2'-[1,3]thiazolidine]-2,4'-dione (CAS 338419-07-1)
- 1-Benzyl-3'-(3,4-dichlorophenyl)spiro[indoline-3,2'-thiazolidine]-2,4'-dione (CAS 861211-75-8)
- 3-(2-{[(2,4-dichlorophenyl)methyl]sulfanyl}pyrimidin-4-yl)-1-(4-methylphenyl)-1,4-dihydropyridazin-4-one (CAS 478077-67-7)
- (5Z)-5-{[(3,4-dichlorophenyl)amino]methylidene}-4-(4-fluorophenyl)-1-(4-methoxyphenyl)-2,5-dihydro-1H-pyrrol-2-one (CAS 339012-09-8)
- 5,6-Bis(3,4-dichlorophenyl)-2-(2-hydroxyethyl)-3-oxo-2,3-dihydropyridazine-4-carbonitrile (CAS 75660-46-7)
- 3-{1-[(2,6-dichlorophenyl)methyl]-2-oxo-1,2-dihydropyridin-3-yl}-1-[3-(trifluoromethyl)phenyl]urea (CAS 400084-72-2)
Recommended Standards
- Ethyl 1-{5-[(1E)-{[(2,4-dichlorophenyl)formamido]imino}methyl]-1,3-thiazol-2-yl}piperidine-4-carboxylate (CAS 477868-56-7)
- [(E)-2-{1-[3,5-bis(trifluoromethyl)phenyl]-4-(pyridine-4-carbonyl)-1H-1,2,3-triazol-5-yl}ethenyl]dimethylamine (CAS 477858-71-2)
- Rebamipide impurity 26 (CAS CATO-C4X-152326)
- Methyl 2-(3,4-dichlorobenzamido)-4-methyl-5-(piperidine-1-carbonyl)thiophene-3-carboxylate (CAS 335406-47-8)
- N-(Isoxazol-4-yl)thiophene-3-carboxamide (CAS 1396867-50-7)
- Ethyl 3-(4-cyanophenyl)prop-2-enoate (CAS 20655-58-7)
- 5-(tert-Butyl)-4-methylisoxazol-3(2H)-one (CAS 95406-69-2)
- Benzene-1,4-bis(carbothioamide) (CAS 13363-51-4)
- (r)-2-((((9h-Fluoren-9-yl)methoxy)carbonyl)amino)-2-(cyclohexa-1,4-dien-1-yl)acetic acid (CAS 1217852-98-6)
- [13C,2H3]-Dexmedetomidine HCl (CAS CATO-C4X-123085)
- NADPH tetrasodium salt (CAS 2646-71-1)
- [3-chloro-5-(methylamino)phenyl]methanol (CAS 1051900-94-7)
- 4-Methylhexan-1-ol (CAS 818-49-5)
- Cholecystokinin Octapeptide (1-5) (desulfated) (CAS 121880-96-4)
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