(E)-[2-(Benzenesulfonyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene][(2,6-dichlorophenyl)methoxy]amine CAS 338758-60-4
| CAS No. | 338758-60-4 |
| Molecular Formula | C21H14Cl3F3N2O3S |
| Molecular Weight | 537.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of (E)-[2-(Benzenesulfonyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene][(2,6-dichlorophenyl)methoxy]amine is closely related to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
(E)-[2-(Benzenesulfonyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene][(2,6-dichlorophenyl)methoxy]amine (CAS 338758-60-4) is a high-purity analytical reference standard with the molecular formula C21H14Cl3F3N2O3S and a molecular weight of 537.77 g/mol.
The molecular framework of (E)-[2-(Benzenesulfonyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene][(2,6-dichlorophenyl)methoxy]amine (C21H14Cl3F3N2O3S) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H14Cl3F3N2O3S |
| Molecular Weight | 537.77 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related E Standards
- (Z)-[2-(Benzenesulfonyl)-1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethylidene][(4-chlorophenyl)methoxy]amine (CAS 672950-28-6)
- Ethyl 2-[2-(benzenesulfonyl)-4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy]propanoate (CAS 338407-15-1)
- (2E)-2-(Benzenesulfonyl)-3-{3-[(2-chloro-6-fluorophenyl)methyl]-2,4-bis(propan-2-yloxy)phenyl}prop-2-enenitrile (CAS 303994-45-8)
- 2-[3-(Benzenesulfonyl)-4-[(4-chlorophenyl)methoxy]phenoxy]-3-chloro-5-(trifluoromethyl)pyridine (CAS 306979-53-3)
- 4-(Benzenesulfonyl)-4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-N-(4-chlorophenyl)butanamide (CAS 338407-60-6)
- (Z)-[2-(Benzenesulfonyl)-1-[2-(4-chlorophenyl)-4-methyl-1,3-thiazol-5-yl]ethylidene][(4-fluorophenyl)methoxy]amine (CAS 672950-32-2)
- 2-[(3AR)-1-(benzenesulfonyl)-3a-methyl-5-oxo-octahydropyrrolo[2,3-b]pyrrol-2-yl]phenyl benzenesulfonate (CAS 957029-95-7)
- 2-(Benzenesulfonyl)-4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl 4-methoxybenzoate (CAS 306979-49-7)
Recommended Standards
- Hexahydro-1-[2,4,8,10-tetrakis(1,1-dimethylethyl)dibenzo[d,f][1,3,2]dioxaphosphepin-6-yl]-1H-azepine (CAS 80399-60-6)
- 2-((4-Chloro-N-(3-(trifluoromethyl)phenyl)phenyl)sulfonamido)-N-(3,5-dichlorophenyl)acetamide (CAS 337922-29-9)
- Selumetinib Impurity 3 (CAS CATO-C4X-30533)
- (5E)-1-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)-5-({[4-(trifluoromethoxy)phenyl]amino}methylidene)-1,3-diazinane-2,4,6-trione (CAS 303144-34-5)
- (Perfluoroethyl)phosphonic acid (CAS 103305-01-7)
- Methyl 3-hydroxy-[1,1'-biphenyl]-4-carboxylate (CAS 117369-94-5)
- 2-(1-((5-Bromothiophen-2-yl)methyl)piperidin-4-yl)acetic acid (CAS 1507587-18-9)
- 3-((2,5-Dibromophenyl)sulfonamido)propanamide (CAS 930964-49-1)
- Zirconyl nitrate solution (CAS 13826-66-9)
- 4-(5-Mercapto-4-(2-morpholinoethyl)-4H-1,2,4-triazol-3-yl)phenol (CAS 917747-24-1)
- Dodecyl octadecylcarbamate (CAS 84967-21-5)
- 2,6-Dichloro-4-(1H-imidazol-2-yl)aniline (CAS 1337882-05-9)
- 6,7-Dimethoxy-N-(prop-2-en-1-yl)quinazolin-4-amine (CAS 477859-94-2)
- Des-Ile12-Aib13-Tirzepatide (CAS CATO-CPTD788960)
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