Selumetinib Impurity 3 CAS CATO-C4X-30533
| CAS No. | CATO-C4X-30533 |
| Molecular Formula | C17H15BrClFN4O6S |
| Molecular Weight | 537.74 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Selumetinib Impurity 3.
Selumetinib Impurity 3 (CAS CATO-C4X-30533) is a certified pharmaceutical impurity reference standard with the molecular formula C17H15BrClFN4O6S and a molecular weight of 537.74 g/mol.
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, Selumetinib Impurity 3 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 537.74 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Selumetinib Impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H15BrClFN4O6S |
| Molecular Weight | 537.74 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 1 |
Related Selumetinib Standards
- Selumetinib Impurity 23 (CAS CATO-C4X-305323)
- Selumetinib Impurity 10 (CAS CATO-C4X-305310)
- Selumetinib Impurity 11 (CAS CATO-C4X-305311)
- Selumetinib Impurity 19 (CAS CATO-C4X-305319)
- Selumetinib Impurity 17 (CAS CATO-C4X-305317)
- Selumetinib (CAS 606143-52-6)
- Selumetinib Impurity N1 (CAS 606144-02-9)
- Selumetinib Impurity 12 (CAS CATO-C4X-305312)
Recommended Standards
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- 4-O-Demtheyl Aliskiren (CAS 949925-74-0)
- (E)-[2-(Benzenesulfonyl)-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]ethylidene][(2,6-dichlorophenyl)methoxy]amine (CAS 338758-60-4)
- Dotinurad Impurity 65 (CAS 38925-98-3)
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- Spiro[4.5]decan-8-one (CAS 4027-35-4)
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- 2702AF 3-(3-Methoxyphenoxy)piperidine 902837-25-6 C12H17NO2 (CAS 902837-25-6)
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