2,2-Difluoro-N-(4-(trifluoromethoxy)phenyl)-2-(3-(trifluoromethyl)phenoxy)acetamide CAS 338792-04-4
| CAS No. | 338792-04-4 |
| Molecular Formula | C16H9F8NO3 |
| Molecular Weight | 415.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2,2-Difluoro-N-(4-(trifluoromethoxy)phenyl)-2-(3-(trifluoromethyl)phenoxy)acetamide (C16H9F8NO3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2,2-Difluoro-N-(4-(trifluoromethoxy)phenyl)-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-04-4), molecular formula C16H9F8NO3 and molecular weight 415.23 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2,2-Difluoro-N-(4-(trifluoromethoxy)phenyl)-2-(3-(trifluoromethyl)phenoxy)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H9F8NO3 |
| Molecular Weight | 415.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 2-(2,6-Difluoro-4-(trifluoromethyl)phenoxy)-4-iodoaniline (CAS 2244083-64-3)
- 2-(2,6-Difluoro-4-(trifluoromethyl)phenoxy)-5-iodoaniline (CAS 2244086-23-3)
- (19E)-4,17-difluoro-1,5,8,13,15,22,27-heptaazatetracyclo[20.2.2.1¹⁰,¹⁴.0²,⁷]heptacosa-2,4,6,10,12,14,19-heptaen-9-one (CAS 2227259-30-3)
- 2-[Difluoro-(3,4,5-trifluorophenoxy)Methyl]-5-(4-ethylphenyl)-1,3-difluoro-benzene (CAS 303186-19-8)
- 1,3-Difluoro-2-(3-fluoro-2-iodophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-68-9)
- 1,3-Difluoro-2-(5-fluoro-2-iodophenoxy)-5-(trifluoromethyl)benzene (CAS 2244087-01-0)
- 1-[(2,2-Difluoro-2H-1,3-benzodioxol-5-yl)methyl]-2-oxo-N-(1-phenylethyl)-1,2-dihydropyridine-3-carboxamide (CAS 400083-12-7)
- 1-Benzyl-6,7-difluoro-3-(phenylsulfonyl)quinolin-4(1H)-one (CAS 899213-86-6)
Recommended Standards
- (3-Amino-6-methyl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl)(4-bromophenyl)methanone (CAS 299198-16-6)
- 5-Bromo-4-{4-methyl-2-[3-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499795-95-8)
- 2-(5-Bromo-2-fluorophenyl)-2-methyl-1-((2-nitrophenyl)sulfonyl)aziridine (CAS 1386986-56-6)
- 5-Bromo-4-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}pyrimidin-2-amine (CAS 499796-53-1)
- n-(4-Methoxybenzyl)pyrimidin-2-amine (CAS 6957-21-7)
- 6-Methoxy-7-methylisoquinolin-1(2h)-one (CAS 209286-01-1)
- 4,4',4''-(Benzene-1,3,5-triyltris(oxy))triphthalic acid (CAS 444717-58-2)
- Methyl 5-fluoro-6-formyl-2-methylnicotinate (CAS 2750929-54-3)
- (R)-2,2,2-Trifluoro-1-(4-methoxyphenyl)ethanamine hydrochloride (CAS 2007916-98-3)
- Ethyl 3-bromo-5-ethoxy-4-((2-fluorobenzyl)oxy)benzoate (CAS 1706446-95-8)
- 5-Cyano-2-methoxyphenylboronic Acid (CAS 612833-37-1)
- {4-[(thien-2-ylsulfonyl)amino]phenyl}acetic acid (CAS 953884-77-0)
- 2-(p-Tolyl)cyclobutanone (CAS 87639-46-1)
- Semaglutide Impurity 11 (CAS CATO-C4X-222611)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com