N-(3,4-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide CAS 338792-05-5
| CAS No. | 338792-05-5 |
| Molecular Formula | C15H8Cl2F5NO2 |
| Molecular Weight | 400.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of N-(3,4-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (C15H8Cl2F5NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
N-(3,4-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-05-5) is a high-purity analytical reference standard with the molecular formula C15H8Cl2F5NO2 and a molecular weight of 400.13 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures N-(3,4-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2F5NO2 |
| Molecular Weight | 400.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related N Standards
- N-(2,4-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-06-6)
- N-(2,6-dichlorophenyl)-2,2-difluoro-2-(3-(trifluoromethyl)phenoxy)acetamide (CAS 338792-20-4)
- 4-(2,4-Dichlorophenyl)-8-(trifluoromethoxy)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline (CAS 342405-95-2)
- 1-[(2,4-Dichlorophenyl)methoxy]-2-(4-methoxyphenyl)-1H-imidazo[4,5-b]pyridine (CAS 339027-99-5)
- 4-(3-(2,4-Dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazolin-5-yl)morpholine (CAS 338977-91-6)
- 4-(3-(3,4-Dichlorophenyl)-[1,2,4]triazolo[4,3-c]quinazolin-5-yl)morpholine (CAS 338977-95-0)
- 2-(3,4-Dichlorophenyl)-6-(3-fluorobenzyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidine (CAS 477850-29-6)
- 5-(2,6-Dichlorophenyl)-2-(phenylthio)-6H-pyrimido[1,6-b]pyridazin-6-one (CAS 209409-98-3)
Recommended Standards
- 5-Methyl-3-(perfluorohexyl)-1H-pyrazole (CAS 129257-23-4)
- 2-{[5-bromo-2-(trifluoromethoxy)phenyl]methyl}isoindole-1,3-dione (CAS 1858255-07-8)
- 4-[3-Chloro-7-(chlorodifluoromethyl)-5-methylpyrazolo[1,5-a]pyrimidin-2-yl]-1-methyl-5-(trifluoromethyl)-1H-pyrazole (CAS 956781-26-3)
- 2,2'-Diselanediyldibenzoic acid (CAS 6512-83-0)
- 2,2-Difluorovinyl 4-methylbenzenesulfonate (CAS 185739-14-4)
- 8-Methoxy-6-nitro-3,4-dihydroquinolin-2(1H)-one (CAS 71280-12-1)
- 2-(Bromomethyl)-5,8-dioxaspiro[3.4]octane (CAS 1057641-71-0)
- Amiodarone-D4 Hydrochloride (CAS 1216715-80-8)
- 4-Amino-3-(1-pyrrolidinyl)pyridine (CAS 144864-27-7)
- N-Phthaloyl-L-glutamic Anhydride (CAS 25830-77-7)
- 5-Isopropyl-5-methyl-2-(methylamino)-1H-imidazol-4(5H)-one (CAS 126973-50-0)
- Ganciclovir Impurity 16 (CAS 88110-89-8)
- 2,5-dimethylthiophene-3-carbaldehyde (CAS 26421-44-3)
- Tirzepatide Impurity 17 (CAS CATO-C4X-324017)
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