1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxyphenyl)-1H-pyrrole-2-carboxamide CAS 338956-38-0
| CAS No. | 338956-38-0 |
| Molecular Formula | C18H13ClF3N3O2 |
| Molecular Weight | 395.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxyphenyl)-1H-pyrrole-2-carboxamide (CAS 338956-38-0) is a high-purity analytical reference standard with the molecular formula C18H13ClF3N3O2 and a molecular weight of 395.76 g/mol.
Based on its molecular formula C18H13ClF3N3O2, 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N-(4-methoxyphenyl)-1H-pyrrole-2-carboxamide contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 395.76 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H13ClF3N3O2 |
| Molecular Weight | 395.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- Ethyl 2-((2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)-5-fluoropyrimidin-4-yl)thio)acetate (CAS 1823182-35-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-3-phenethylpyrimidine-2,4(1H,3H)-dione (CAS 251310-60-8)
- 2-[(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]amino}ethyl)amino]-1,4-dihydronaphthalene-1,4-dione (CAS 303152-84-3)
- Methyl 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoropyridin-2-yl)-6-methyl-1,4-dihydropyrimidine-5-carboxylate (CAS 298708-79-9)
- 3-{[2-chloro-6-(1H-1,2,4-triazol-1-yl)phenyl]methyl}-1-[3-(trifluoromethyl)phenyl]urea (CAS 866042-61-7)
- 2-Chloro-5-{[4-(trifluoromethoxy)phenyl]sulfamoyl}benzoic acid (CAS 745798-18-9)
- N-(4-chloro-3-nitrophenyl)-2-((4-methyl-5-(trifluoromethyl)-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 329778-13-4)
- N-[3-Chloro-5-(trifluoromethyl)-2-pyridinyl]-4-methoxy-N-methylbenzenesulfonohydrazide (CAS 339276-30-1)
Recommended Standards
- Bay 41-4109 (CAS 298708-81-3)
- 38725-13-2 CTK4I0375 Isononanamine,N,N-diisononyl- (9CI) (CAS 38725-13-2)
- BAy 41-4109 (less active enantiomer) (CAS 476617-51-3)
- Trinonylamine (CAS 2044-22-6)
- 3-(Benzo[b]thiophen-2-yl)phenol (CAS 95935-60-7)
- N-Allyl-N-(pyren-1-ylmethyl)prop-2-en-1-amine (CAS 102592-39-2)
- Ethyl 2-(7-methoxy-3-methylquinoxalin-2-yl)acetate (CAS 1707371-42-3)
- 2-Chloro-6-(pyrrolidin-1-yl)pyridine (CAS 117362-51-3)
- FXa-IN-1 (CAS 441328-10-5)
- Ethyl 2-(3-cyclopropyl-6-methyl-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl)acetate (CAS 1018141-86-0)
- Ruxolitinib Impurity N6 (CAS 941685-39-8)
- 4-Ethyl-2-methylthiophen-3-amine (CAS 87675-31-8)
- p-Tolyl Phenylacetate (CAS 101-94-0)
- Semaglutide impurity 205 (CAS CATO-C4X-2226205)
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