2-((4-Chloro-N-(2,4-dichloro-5-methoxyphenyl)phenyl)sulfonamido)-N-(2,4-difluorophenyl)acetamide CAS 338961-81-2
| CAS No. | 338961-81-2 |
| Molecular Formula | C21H15Cl3F2N2O4S |
| Molecular Weight | 535.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-((4-Chloro-N-(2,4-dichloro-5-methoxyphenyl)phenyl)sulfonamido)-N-(2,4-difluorophenyl)acetamide.
2-((4-Chloro-N-(2,4-dichloro-5-methoxyphenyl)phenyl)sulfonamido)-N-(2,4-difluorophenyl)acetamide (CAS 338961-81-2), molecular formula C21H15Cl3F2N2O4S and molecular weight 535.78 g/mol, is a CATO reference standard with documented purity and traceability.
2-((4-Chloro-N-(2,4-dichloro-5-methoxyphenyl)phenyl)sulfonamido)-N-(2,4-difluorophenyl)acetamide (C21H15Cl3F2N2O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H15Cl3F2N2O4S |
| Molecular Weight | 535.78 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 1-Ethyl-8-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (CAS 1018135-10-8)
- LY 272015 Hydrochloride (CAS 172895-15-7)
- (S)-2-((tert-Butoxycarbonyl)amino)-3-(4-hydroxyphenyl)-2-methylpropanoic acid (CAS 74825-83-5)
- 3-Vinylcyclohexan-1-one (CAS 1740-63-2)
- 9-Ethyl-9H-purin-6-ol (CAS 31010-51-2)
- 5,6-Dibromo-1,1,2,2,3,3-hexamethyl-2,3-dihydro-1H-indene (CAS 1541101-19-2)
- Amd 15057 (CAS 327613-57-0)
- 1-(2-Diethylamino-ethyl)-1H-pyrazol-4-ylamine dihydrochloride (CAS 1426290-14-3)
- Pancreatic Polypeptide (31-36) Free Acid, human (CAS 192432-73-8)
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