2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-morpholinopropyl)malonamide CAS 478063-84-2
| CAS No. | 478063-84-2 |
| Molecular Formula | C23H33ClF3N5O4 |
| Molecular Weight | 535.99 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-morpholinopropyl)malonamide (CAS 478063-84-2), molecular formula C23H33ClF3N5O4 and molecular weight 535.99 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-morpholinopropyl)malonamide (C23H33ClF3N5O4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-N1,N3-bis(3-morpholinopropyl)malonamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C23H33ClF3N5O4 |
| Molecular Weight | 535.99 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 5 |
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Recommended Standards
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- Nirmatrelvir Impurity 3 (CAS CATO-C4X-28743)
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- 4-Ethoxy-3-(3-methylureido)benzenesulfonyl chloride (CAS 678186-10-2)
- 1,10-Bis(ethylsulfinyl)decane (CAS 28242-23-1)
- 3-Amino-6-(4-methyl-1-piperazinyl)pyridine (CAS 55403-35-5)
- 1-Ethyl-5-methyl-1H,2H-3,4-bipyrazol-5-amine (CAS 943107-19-5)
- N-(tert-butyl)-5-chlorothiophene-2-sulfinamide (CAS 957299-22-8)
- tert-Butyl 3-[(5-nitropyridin-2-yl)oxy]piperidine-1-carboxylate (CAS 939986-60-4)
- Dopamine Impurity 76 (CAS CATO-C4X-151476)
- 1-Methyl-N-(1-(thiophen-2-yl)ethyl)piperidin-4-amine (CAS 1038219-18-9)
- 8-Bromo-3-iodoquinoline (CAS 917251-85-5)
- Human glucagon CRS (CAS 9007-92-5)
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