Ethyl 1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate CAS 338965-01-8
| CAS No. | 338965-01-8 |
| Molecular Formula | C16H17ClF3N3O3 |
| Molecular Weight | 391.77 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Ethyl 1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 338965-01-8), molecular formula C16H17ClF3N3O3 and molecular weight 391.77 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Ethyl 1-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (C16H17ClF3N3O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17ClF3N3O3 |
| Molecular Weight | 391.77 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- 2-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepane-1-carbonyl}cyclopropane-1-carboxylic acid (CAS 1024151-62-9)
- Ethyl 3-(2-chloro-6-fluorophenyl)-2-(1-(6-fluoropyridin-2-yl)-1H-pyrazol-5-yl)propanoate (CAS 477709-64-1)
- Ethyl 4-{[2-chloro-5-(trifluoromethyl)phenyl]amino}-2-(methylsulfanyl)pyrimidine-5-carboxylate (CAS 339019-46-4)
- Ethyl 3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-2,4-dioxo-3-azabicyclo[3.1.0]Hexane-6-carboxylate (CAS 318237-93-3)
- 2-[2-chloro-5-(trifluoromethyl)benzenesulfonamido]-4-(methylsulfanyl)butanoic acid (CAS 1008945-26-3)
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Recommended Standards
- CTEP (RO4956371) (CAS 871362-31-1)
- 5-((5-(Trifluoromethyl)pyridin-2-yl)sulfonyl)thiophene-2-sulfonyl chloride (CAS 175202-87-6)
- 2-((4-Chlorobenzyl)sulfonyl)-N-(3-(trifluoromethyl)phenyl)acetamide (CAS 339107-23-2)
- 3-Bromo-6-chloro-5-methoxy-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazole (CAS 2769085-15-4)
- (R)-(+)-2-Amino-3-phenyl-1-propanol (CAS 5267-64-1)
- 2-[3-(Trifluoromethyl)phenoxy]propanoyl chloride (CAS 303181-61-5)
- 3-acetamidobicyclo[1.1.1]pentan-1-yl 2-(acetyloxy)benzoate (CAS 1628196-28-0)
- 1,4-Bis[(2,5-dimethylphenyl)methyl]benzene (CAS 15742-68-4)
- rel-(2R,4S)-Pentane-2,4-diol (CAS 3950-21-8)
- Methyl (4-fluorophenyl)(4-phenylpiperazin-1-yl)-acetate hydrobromide (CAS 1063629-70-8)
- 2-Methyl-5-pentyl-3-phenylisoxazolidine (CAS 19969-14-3)
- (R)-Ethyl 2-(1-((tert-butoxycarbonyl)amino)ethyl)thiazole-4-carboxylate (CAS 111946-75-9)
- 3-(2-methylphenyl)propan-1-amine (CAS 76293-74-8)
- Tirzepatide Impurity 18 (CAS CATO-C4X-324018)
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