6-Amino-4-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyrimidin-2-one CAS 338965-02-9
| CAS No. | 338965-02-9 |
| Molecular Formula | C18H13ClF6N6O |
| Molecular Weight | 478.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies 6-Amino-4-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyrimidin-2-one (CAS 338965-02-9), a certified reference material (molecular formula C18H13ClF6N6O, MW 478.78 g/mol) for analytical method development and quality control.
The molecular framework of 6-Amino-4-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyrimidin-2-one (C18H13ClF6N6O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C18H13ClF6N6O |
| Molecular Weight | 478.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 6 |
Related Amino Standards
- 6-Amino-7-((4-chlorophenyl)sulfonyl)-5-(4-ethoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine-2,3-dicarbonitrile (CAS 691396-68-6)
- 4-Amino-N-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide (CAS 1446113-23-0)
- N-(6-Amino-3-methyl-2,4-dioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-dibutyl-4-hydroxybenzamide (CAS 176370-46-0)
- N-(6-Amino-3-methyl-2,4-dioxo-1-(p-tolyl)-1,2,3,4-tetrahydropyrimidin-5-yl)-3,5-di-tert-butyl-4-hydroxybenzamide (CAS 176378-80-6)
- N-(2-Amino-3,8-dimethylimidazo[4,5-f]quinoxalin-5-yl) 2-Deoxyguanosine (CAS 142038-30-0)
- (8E)-2-Amino-4-[2-(trifluoromethyl)phenyl]-8-{[2-(trifluoromethyl)phenyl]methylidene}-4H,5H,7H,8H-pyrano[3,2-c]pyran-3-carbonitrile (CAS 445390-77-2)
- 4-(2-Amino-6-oxo-1H-purin-9(6H)-yl)-2-hydroxybutyl tetrahydrogen triphosphate (CAS 108491-46-9)
- 3-Amino-N-(2,4-dimethoxyphenyl)-6-ethyl-4-(trifluoromethyl)-5,6,7,8-tetrahydrothieno[2,3-b]quinoline-2-carboxamide (CAS 939893-77-3)
Recommended Standards
- 3-[(1E)-1-{2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methylhydrazin-1-yl}-2-cyanoeth-1-en-1-yl]-1-[3-(trifluoromethyl)phenyl]urea (CAS 337920-17-9)
- 3,3'-(ethane-1,2-diylbis(sulfanediyl))bis(1-(2,6,6-trimethylcyclohex-1-en-1-yl)butan-1-one) (CAS CATO-C3D-262391)
- 1-(3-Chlorobenzyl)-3-(5-((2,4-dichlorobenzyl)thio)-1,3,4-oxadiazol-2-yl)pyridin-2(1H)-one (CAS 477852-94-1)
- 1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-N'-[(1E)-[3-(trifluoromethyl)phenyl]methylidene]piperidine-4-carbohydrazide (CAS 338761-42-5)
- [2-(2H-1,2,3-Triazol-4-yl)ethyl]amine hydrochloride (CAS 1820619-62-2)
- (R)-3-Amino-2-(2,4-difluorobenzyl)propanoic acid (CAS 1260610-40-9)
- Methyl 5-bromo-2-hydroxy-4-methoxybenzoate (CAS 39503-52-1)
- 5-[1-(4-Chloro-phenyl)-1H-tetrazol-5-yl]-4-phenyl-pyrimidin-2-ylamine (CAS 139393-52-5)
- Avatrombopag Impurity 60 (CAS CATO-C4X-223460)
- 2,3-Difluoro-4-(hydroxymethyl)phenylboronic acid (CAS 1315281-32-3)
- 1-(3-(2,2,2-Trifluoroethoxy)propyl)-1h-pyrazol-3-amine (CAS 1247114-07-3)
- n-(Sec-butyl)-3-(3,5-dimethyl-1h-pyrazol-1-yl)propanamide (CAS 1311931-91-5)
- 3-(2,5-Dichlorophenyl)-2-methyl-1-propene (CAS 93794-96-8)
- Palmitoyl hexapeptide-6 (CAS 891498-01-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com