1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide CAS 338977-33-6
| CAS No. | 338977-33-6 |
| Molecular Formula | C14H9Cl2F3N2O2 |
| Molecular Weight | 365.13 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide.
1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-33-6), molecular formula C14H9Cl2F3N2O2 and molecular weight 365.13 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (C14H9Cl2F3N2O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(3,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H9Cl2F3N2O2 |
| Molecular Weight | 365.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichlorobenzyl Standards
- 1-(2,4-Dichlorobenzyl)-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (CAS 242797-40-6)
- N-(1-(2,6-dichlorobenzyl)-2-oxo-1,2-dihydropyridin-3-yl)-2,2,2-trifluoroacetamide (CAS 338784-31-9)
- Ethyl 3-(2,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate (CAS 339013-43-3)
- Ethyl 3-(3,4-dichlorobenzyl)-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-1-carboxylate (CAS 339013-49-9)
- 2-(5-((2,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 578733-34-3)
- 2-(5-((2,6-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 618415-01-3)
- 2-(5-((3,4-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 618414-77-0)
- 3-(5-((2,6-Dichlorobenzyl)thio)-4-ethyl-4H-1,2,4-triazol-3-yl)pyridine (CAS 618426-51-0)
Recommended Standards
- 1-(3,4-Dichlorophenyl)-3-(4-(trifluoromethoxy)phenyl)urea (CAS 54730-76-6)
- 2-(2H-1,3-Benzodioxol-5-yl)-3-iodoimidazo[1,2-a]pyrimidine (CAS 1426142-92-8)
- 1-[(2,6-Dichlorophenyl)methyl]-2-oxo-6-(trifluoromethyl)-1,2-dihydropyridine-3-carboxamide (CAS 338977-34-7)
- 6-Iodo-9-oxo-9,10-dihydroacridine-4-carboxylic acid (CAS 86611-62-3)
- 2-(Trifluoromethyl)-benzeneacetonitrile (CAS 3038-47-9)
- 6-(Difluoromethoxy)-2,3-difluorobenzonitrile (CAS 221202-16-0)
- (Furan-2-ylmethyl)(pyridin-3-ylmethyl)amine (CAS 460046-47-3)
- 2-(1,3-Dimethyl-1h-1,2,4-triazol-5-yl)propan-2-amine (CAS 1248726-99-9)
- tert-butyl trans-4-(hydroxymethyl)cyclohexanecarboxylate (CAS 1943744-53-3)
- 1-(4-Fluoro-2-nitrophenyl)-1h-pyrazole-3-carboxylic acid (CAS 1006442-84-7)
- N-[(E)-(4-tert-Butylphenyl)methylideneamino]-4-methylbenzenesulfonamide (CAS 65609-73-6)
- 6-Chloro-N2,N4-diphenyl-1,3,5-triazine-2,4-diamine (CAS 1973-09-7)
- (E)-1-(2-(Furan-2-yl)vinyl)cyclopropanamine (CAS 604800-01-3)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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