5-Chloro-N-[2-(dimethylamino)ethyl]-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide CAS 338977-54-1
| CAS No. | 338977-54-1 |
| Molecular Formula | C18H19ClF3N3O2 |
| Molecular Weight | 401.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, 5-Chloro-N-[2-(dimethylamino)ethyl]-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 401.81 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
5-Chloro-N-[2-(dimethylamino)ethyl]-2-oxo-1-{[3-(trifluoromethyl)phenyl]methyl}-1,2-dihydropyridine-3-carboxamide (CAS 338977-54-1), molecular formula C18H19ClF3N3O2 and molecular weight 401.81 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H19ClF3N3O2 |
| Molecular Weight | 401.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 5-Chloro-N-(2-(dimethylamino)ethyl)-6-oxo-1-(3-(trifluoromethyl)benzyl)-1,6-dihydropyridine-3-carboxamide (CAS 338981-07-0)
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- 2-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-1-[4-(4-fluorophenyl)piperazin-1-yl]ethan-1-one (CAS 444151-88-6)
- 4-(2-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]sulfanyl}-4,5-dihydro-1H-imidazol-1-yl)benzoic acid (CAS 321433-53-8)
- Methyl 4-((4'-chloro-[1,1'-biphenyl])-4-sulfonamido)benzoate (CAS 1182284-29-2)
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Recommended Standards
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- 5,7-Dibromo-3-iodo-1H-indazole (CAS 1131632-64-8)
- Lenvatinib Impurity 172 (CAS CATO-C4X-1140172)
- 6-Amino-2-methylthio-3-methyluracil (CAS 54030-56-7)
- 1-Cyclopentyl-1H-pyrazolo[3,4-b]pyrazin-3-amine (CAS 1443291-78-8)
- 3-(4-Fluoro-3-methylphenoxy)piperidine (CAS 954225-94-6)
- 2,2'-[Propylenebis(nitriloethylidyne)]di-phenol (CAS 13294-00-3)
- (2-((tert-Butoxycarbonyl)amino)pyrimidin-5-yl)boronic acid (CAS 883231-25-2)
- 2-(4-Amino-6-methyl-1,3,5-triazin-2-yl)phenol (CAS 146998-57-4)
- (S,R,S)-AHPC--CO-PEG1-C2-amine HCl (CAS 2254643-69-9)
- N-[2-(2,4-Dichlorophenoxy)ethyl]-2-fluoroaniline (CAS 1040685-71-9)
- 2-(4-(Tert-butoxycarbonyl)piperazin-1-yl)-2-(2,4-dimethoxyphenyl)acetic acid (CAS 1400644-22-5)
- Acetyl Tripeptide-1 (CAS 350595-76-5)
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