1-{[5-(2-chlorophenyl)-1,2-oxazol-3-yl]methyl}-4-(2-fluorophenyl)piperazine CAS 339019-77-1
| CAS No. | 339019-77-1 |
| Molecular Formula | C20H19ClFN3O |
| Molecular Weight | 371.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-{[5-(2-chlorophenyl)-1,2-oxazol-3-yl]methyl}-4-(2-fluorophenyl)piperazine is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 1-{[5-(2-chlorophenyl)-1,2-oxazol-3-yl]methyl}-4-(2-fluorophenyl)piperazine (CAS 339019-77-1), a certified reference material (molecular formula C20H19ClFN3O, MW 371.84 g/mol) for analytical method development and quality control.
1-{[5-(2-chlorophenyl)-1,2-oxazol-3-yl]methyl}-4-(2-fluorophenyl)piperazine (C20H19ClFN3O) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H19ClFN3O |
| Molecular Weight | 371.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chlorophenyl Standards
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- 1-{[5-(4-chlorophenyl)-1,2-oxazol-3-yl]methyl}-4-(2-fluorophenyl)piperazine (CAS 343374-68-5)
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Recommended Standards
- (1S,2S)-2-(4-(5-((5-Chloropyridin-2-yl)thio)-1H-imidazol-4-yl)phenyl)cyclopropanecarboxylic acid (CAS 1242441-49-1)
- 10-(2-Chloro-6-fluorophenyl)-7,7-dimethyl-5,6,7,8,10,11-hexahydro-9H-benzo[e]pyrido[2,3-b][1,4]diazepin-9-one (CAS 1022505-60-7)
- Lincomycin Impurity 29 (CAS CATO-C4X-134229)
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- (R)-1-(4-bromo-3-methylphenyl)but-3-en-1-amine (CAS 1270042-18-6)
- Methyl (2-nitrophenyl)sulfane (CAS 3058-47-7)
- 4-Cycloheptyl-5-[3-(morpholine-4-sulfonyl)-phenyl]-4H-[1,2,4]triazole-3-thiol (CAS 522624-42-6)
- 1-(4-(4-Pentylcyclohexyl)phenyl)-3-(2-(pyrrolidin-1-yl)ethyl)urea (CAS 866137-22-6)
- 3,5-DImethyl-4-[(e)-phenyldiazenyl]phenol (CAS 1778-71-8)
- 2-(2-Methylphenyl)benzoic acid (CAS 7111-77-5)
- 5-(Benzyloxy)-4-chloro-2-(chloromethyl)pyridine (CAS 62811-98-7)
- 2-(1-Adamantyl)-4,5-dihydro-1H-imidazole (CAS 52725-79-8)
- 6-Bromo-3,7-diiodo-4-methoxy(1H)indazole (CAS 1082040-60-5)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
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