2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[3-(trifluoromethyl)phenyl]propanamide CAS 339275-77-3
| CAS No. | 339275-77-3 |
| Molecular Formula | C18H15F6NO4S |
| Molecular Weight | 455.37 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[3-(trifluoromethyl)phenyl]propanamide.
2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[3-(trifluoromethyl)phenyl]propanamide (CAS 339275-77-3) is a high-purity analytical reference standard with the molecular formula C18H15F6NO4S and a molecular weight of 455.37 g/mol.
The molecular framework of 2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[3-(trifluoromethyl)phenyl]propanamide (C18H15F6NO4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H15F6NO4S |
| Molecular Weight | 455.37 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Hydroxy Standards
- 2-Hydroxy-2-methyl-3-[3-(trifluoromethyl)benzenesulfonyl]-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-14-2)
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Recommended Standards
- 2-Bromo-N-(4-(N-(2,6-dimethylpyrimidin-4-yl)sulfamoyl)phenyl)hexanamide (CAS 380467-37-8)
- 1, 4-PREGNADIEN-9α, 11β-DICHLORO-17, 21-DIOL-3, 20-DIONE 21-ACETATE (CAS 79-61-8)
- 5-Fluoro-1-(4-fluorobenzyl)pyrimidine-2,4(1H,3H)-dione (CAS 86547-17-3)
- (2S,3S,4S,5R,6S)-2-(methoxycarbonyl)-6-(2-nitrophenoxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 55274-44-7)
- 4-Hydroxy-4-(3-methyl-4-propoxyphenyl)butanoic acid (CAS 879053-91-5)
- N-benzyl-2-(4-iodo-1H-pyrazol-1-yl)acetamide (CAS 956691-13-7)
- 4-(Difluoromethyl)-5-iodo-6-(trifluoromethyl)pyridin-2-ol (CAS 1806936-36-6)
- 3-(M-tolyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidine-7-thiol (CAS 1082437-14-6)
- 1-[(2,5-Difluorophenyl)methyl]-1H-pyrazol-4-amine (CAS 1240574-07-5)
- 2-(3,5-Dioxo-4-aza-tricyclo[5.2.1.0*2,6*]-dec-8-en-4-yl)propionic acid (CAS 353746-54-0)
- 2-Ethyl-2-methylpiperidine (CAS 585544-35-0)
- N-ethyl-3-fluoropyridin-2-amine (CAS 220714-70-5)
- 4-(4-Isopropylphenyl)-4,5,6,7-tetrahydro-3H-imidazo[4,5-c]pyridine (CAS 303021-39-8)
- Peptide 437 (CAS CATO-CPTD788437)
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