Tenofovir Alafenamide Impurity 1 CAS 342631-41-8
| CAS No. | 342631-41-8 |
| Molecular Formula | C21H22N5O4P |
| Molecular Weight | 439.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Tenofovir Alafenamide Impurity 1 (CAS 342631-41-8) is a certified pharmaceutical impurity reference standard with the molecular formula C21H22N5O4P and a molecular weight of 439.40 g/mol.
Based on its molecular formula C21H22N5O4P, Tenofovir Alafenamide Impurity 1 contains a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 439.40 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures Tenofovir Alafenamide Impurity 1 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C21H22N5O4P |
| Molecular Weight | 439.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 5 |
Related Tenofovir Standards
- Tenofovir disoproxil Impurity 137 (CAS CATO-C4X-1076137)
- Tenofovir disoproxil Impurity 54 (CAS 1878175-76-8)
- Tenofovir alafenamide Impurity 14 (CAS 1234081-04-9)
- Tenofovir disoproxil Impurity 21 (CAS 1244022-55-6)
- Tenofovir Diphosphate (CAS 166403-66-3)
- Tenofovir disoproxil Impurity 113 (CAS CATO-C4X-1076113)
- Tenofovir disoproxil Impurity 100 (CAS 1796539-92-8)
- Tenofovir alafenamide Impurity 16 Free base (CAS CATO-C4X-179769)
Recommended Standards
- α-D-Mannopyranoside, 4-aminophenyl, 2,3,4,6-tetraacetate (CAS 187146-99-2)
- N-[3,5-Bis(trifluoromethyl)benzenesulfonyl]-l-methionyl hydrazide (CAS 209056-83-7)
- (S)-Fmoc-2,6-Difluorotyrosine (CAS 273221-87-7)
- 3-{[(3,4-dichlorophenyl)methyl]sulfanyl}-1-(3-methylphenyl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile (CAS 439107-40-1)
- Rosuvastatin Impurity 251 (CAS 1416000-51-5)
- Gadoxetate Impurity 11 (CAS 221640-06-8)
- Dacarbazine EP Impurity C (CAS 1314929-56-0)
- 2-(Benzylsulfanyl)-6-chloropyrazine (CAS 33870-91-6)
- Methyl 4-(5-nitropyridin-2-yl)butanoate (CAS 1398048-72-0)
- 4-Bromo-2-tert-Butylbenzoic acid (CAS 14034-99-2)
- 1,3,3,7-Tetramethylindolin-2-one (CAS 344287-38-3)
- Di-tert-butyl (3-chloroisoquinolin-5-yl)iminodicarbonate (CAS 2589698-10-0)
- N-(Morpholin-2-ylmethyl)methanesulfonamide (CAS 1153762-77-6)
- Ginseng Tetrapeptide (CAS 178553-95-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com