9-(4-Methoxyphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine CAS 343372-39-4
| CAS No. | 343372-39-4 |
| Molecular Formula | C18H10F6N4O |
| Molecular Weight | 412.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 412.29 g/mol gives 9-(4-Methoxyphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies 9-(4-Methoxyphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine (CAS 343372-39-4), a certified reference material (molecular formula C18H10F6N4O, MW 412.29 g/mol) for analytical method development and quality control.
The molecular framework of 9-(4-Methoxyphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine (C18H10F6N4O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 9-(4-Methoxyphenyl)-2,4-bis(trifluoromethyl)-[1,2,4]triazolo[4,3-a][1,8]naphthyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C18H10F6N4O |
| Molecular Weight | 412.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Related Methoxyphenyl Standards
- 3-(1-(4-Methoxyphenyl)-1H-pyrazol-3-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one (CAS 318498-03-2)
- 5-((4-Methoxyphenyl)sulfonyl)-7-(trifluoromethyl)-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinoxaline (CAS 860785-72-4)
- 2-(2-(4-(4-Methoxyphenyl)piperazin-1-yl)ethyl)-6-nitro-2H-benzo[b][1,4]oxazin-3(4H)-one (CAS 866133-23-5)
- 2-{2-[4-(4-methoxyphenyl)piperazin-1-yl]ethyl}-7-nitro-3,4-dihydro-2H-1,4-benzoxazin-3-one (CAS 866137-65-7)
- 4-(2-(4-Methoxyphenyl)-3-methylquinoline-4-carboxamido)benzoic acid (CAS 495377-79-2)
- N2-(4-methoxyphenyl)-N4,N6-di-m-tolyl-1,3,5-triazine-2,4,6-triamine (CAS 628725-21-3)
- (1-((4-Methoxyphenyl)sulfonyl)piperidine-4-carbonyl)-L-leucine (CAS 1212389-18-8)
- 1-[(3-Methoxyphenyl)methyl]-3-{1-[3-(thiophen-3-yl)-1,2,4-oxadiazol-5-yl]cyclohexyl}urea (CAS 1396680-11-7)
Recommended Standards
- 2-Phenyl-5-(trifluoromethyl)-6-[4-(trifluoromethyl)benzoyl]-2,3-dihydropyridazin-3-one (CAS 478043-64-0)
- N-[2-(Pyridin-3-yl)pyrimidin-4-yl]-3,5-bis(trifluoromethyl)benzamide (CAS 866143-29-5)
- 2-(4-Bromophenyl)-1-(4-fluorophenyl)-6,6-dimethyl-1,5,6,7-tetrahydro-4H-indol-4-one (CAS 96757-24-3)
- Enzalutamide Impurity 29 (CAS CATO-C4X-101629)
- tert-Butyl 3-bromo-2-oxo-1,5,7,8-tetrahydro-1,6-naphthyridine-6(2H)-carboxylate (CAS 1036381-92-6)
- Tert-butyl (R)-3,3-difluoro-5-(3-oxobutanoyl)piperidine-1-carboxylate (CAS 2227198-77-6)
- (E)-Ethyl cinnamoylcarbamate (CAS 143816-12-0)
- N,N-diethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 1311165-58-8)
- N-(4-Aminopiperazin-1-yl)-3-phenylpropanamide (CAS 1956309-49-1)
- (S)-tert-Butyl 5-bromo-2-((tert-butoxycarbonyl)amino)pentanoate (CAS 91229-86-6)
- N-propylchlorothioformate (CAS 13889-92-4)
- Rel-2-((1R,5S)-8-oxo-1,3,4,5,6,8-hexahydro-2H-1,5-methanopyrido[1,2-a][1,5]diazocine-3-carboxamido)-2-phenylacetic acid (CAS 1435803-92-1)
- 3-(5-Methoxybenzo[d]thiazol-2-yl)-2-phenylquinazolin-4(3H)-one (CAS 918154-63-9)
- Semaglutide impurity 101 (CAS CATO-C4X-2226101)
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