7-Chloro-2-methyl-5-oxo-N-(pyridin-4-ylmethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide CAS 343375-48-4
| CAS No. | 343375-48-4 |
| Molecular Formula | C20H14ClN3O3 |
| Molecular Weight | 379.80 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 7-Chloro-2-methyl-5-oxo-N-(pyridin-4-ylmethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
7-Chloro-2-methyl-5-oxo-N-(pyridin-4-ylmethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 343375-48-4), molecular formula C20H14ClN3O3 and molecular weight 379.80 g/mol, is a CATO reference standard with documented purity and traceability.
7-Chloro-2-methyl-5-oxo-N-(pyridin-4-ylmethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide (C20H14ClN3O3) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Chloro-2-methyl-5-oxo-N-(pyridin-4-ylmethyl)-5H-chromeno[2,3-b]pyridine-3-carboxamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H14ClN3O3 |
| Molecular Weight | 379.80 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
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- (E)-6-chloro-2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde O-(3-fluorobenzyl) oxime (CAS 866136-70-1)
- 2-(4-Chloro-phenyl)-imidazo[1,2-a]pyridine-3-carboxaldehyde (CAS 478257-35-1)
- 4-(2-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)benzenesulfonamide (CAS 321432-11-5)
- Benzyl 7-chloro-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylate (CAS 343375-50-8)
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Recommended Standards
- N'-(4-chlorobenzoyl)-3-(1H-pyrrol-1-yl)benzofuran-2-carbohydrazide (CAS 866040-18-8)
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- 3-(2-Chlorophenyl)-N-[(3-phenyl-1,2-oxazol-5-yl)methyl]-1,2-oxazole-5-carboxamide (CAS 478043-66-2)
- 10-Chlorobenzo[e]benzo[4,5]imidazo[1,2-c][1,2,3]triazine (CAS 10211-11-7)
- 5-(3-(Trifluoromethyl)phenyl)tetrahydrofuran-2-carboxamide (CAS 1421603-42-0)
- [S(R)]-N-[(R)-[6-(Diphenylphosphino)benzo[d][1,3]dioxol-5-yl]phenylmethyl]-2-methyl-2-propanesulfinamide (CAS 2565792-84-7)
- Methyl octadec-17-enoate (CAS 18654-84-7)
- 2-Ethoxy-6,7-difluoroquinoxaline (CAS 709638-76-6)
- 2-((1-(Aminomethyl)-3-methylcyclopentyl)oxy)ethan-1-ol (CAS 1487077-63-3)
- 1-(4-chloro-2-iodo-phenyl)hexahydropyrimidine-2,4-dione (CAS 1701676-45-0)
- 2-((4-Amino-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(m-tolyl)acetamide (CAS 811468-71-0)
- (4-(Methylthio)benzo[d]oxazol-2-yl)methanol (CAS 1804086-60-9)
- Famotidine impurity 69 (CAS 850864-53-8)
- Semaglutide impurity 273 (CAS CATO-C4X-2226273)
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