7-Chloro-N,N-diethyl-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide CAS 343375-47-3
| CAS No. | 343375-47-3 |
| Molecular Formula | C18H17ClN2O3 |
| Molecular Weight | 344.79 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 7-Chloro-N,N-diethyl-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide.
CATO supplies 7-Chloro-N,N-diethyl-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 343375-47-3), a certified reference material (molecular formula C18H17ClN2O3, MW 344.79 g/mol) for analytical method development and quality control.
The molecular framework of 7-Chloro-N,N-diethyl-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (C18H17ClN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H17ClN2O3 |
| Molecular Weight | 344.79 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 3-(4-Chlorophenyl)-1-methyl-4-(4-nitrobenzoyl)pyrrolidine (CAS 338750-28-0)
- N-(tert-butyl)-7-chloro-2-methyl-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxamide (CAS 343375-46-2)
- 2-[4-(3-chlorophenyl)piperazine-1-carbonyl]benzoic acid (CAS 841270-53-9)
- Tolvaptan Impurity 70 (CAS CATO-C4X-195570)
- 8-Benzyl-3-oxa-8-azabicyclo[3.2.1]octane (CAS 1187087-20-2)
- 2-Isobutyl-N-(4-methoxyphenyl)quinoline-4-carboxamide (CAS 332358-01-7)
- 4-(4-Chlorophenoxy)-2-phenylpyrimidine-5-carboxylic acid (CAS 477859-46-4)
- 1-Cyclopentyl-3-nitro-1H-pyrazole-4-carboxamide (CAS 1795275-38-5)
- 1-(1-Oxa-4-thia-8-azaspiro[4.5]decan-8-yl)-2-(thiophen-3-yl)ethan-1-one (CAS 1797617-35-6)
- 2,4-dichloroquinazoline-7-carboxylic acid (CAS 879274-85-8)
- 5-Guanylic Acid ·X Sodium Salt (CAS 13474-02-7)
- 2-(3,4-Difluorophenoxy)-5-(trifluoromethyl)aniline (CAS 946728-17-2)
- 1,5,6-Trimethyl-4-nitro-1H-1,3-benzodiazole (CAS 338410-74-5)
- Semaglutide impurity 210 (CAS CATO-C4X-2226210)
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