Estradiol Impurity 24 CAS 3434-88-6
| CAS No. | 3434-88-6 |
| Molecular Formula | C22H28O4 |
| Molecular Weight | 356.46 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Estradiol Impurity 24 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Estradiol Impurity 24 (CAS 3434-88-6), a pharmacopoeial impurity reference standard (molecular formula C22H28O4, MW 356.46 g/mol) used for the identification and quantification of trace impurities in APIs.
Estradiol Impurity 24 (C22H28O4) contains a flavonoid core, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C22H28O4 |
| Molecular Weight | 356.46 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
Related Estradiol Standards
- Estradiol 17-Isovalerate (CAS 869627-83-8)
- Estradiol Valerate EP Impurity B (CAS 21881-45-8)
- 17-Beta-Estradiol 17-Valerate (CAS 979-32-8)
- Estradiol Valerate 17α-Isomer (CAS 182624-54-0)
- Estradiol Valerate EP Impurity C (CAS 95959-20-9)
- Estradiol Valerate EP Impurity G (CAS 1313382-25-0)
- Estradiol-7α-butyric Acid (CAS 55592-40-0)
- ∆9(11)-Estradiol Diacetate (CAS 1169-54-6)
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