1-[4-chloro-3-(trifluoromethyl)phenyl]ethan-1-ol CAS 348-84-5
| CAS No. | 348-84-5 |
| Molecular Formula | C9H8ClF3O |
| Molecular Weight | 224.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
1-[4-chloro-3-(trifluoromethyl)phenyl]ethan-1-ol (CAS 348-84-5) is a high-purity analytical reference standard with the molecular formula C9H8ClF3O and a molecular weight of 224.61 g/mol.
1-[4-chloro-3-(trifluoromethyl)phenyl]ethan-1-ol (C9H8ClF3O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H8ClF3O |
| Molecular Weight | 224.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related chloro Standards
- 3-Chloro-N-ethyl-5-(trifluoromethyl)pyridin-2-amine (CAS 1042499-48-8)
- 2-chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (CAS 1070686-96-2)
- (1R)-2-chloro-1-[4-(trifluoromethyl)phenyl]ethan-1-ol (CAS 1072105-58-8)
- 6-Chloro-N,N-dimethyl-4-(trifluoromethyl)pyridin-2-amine (CAS 1160994-88-6)
- 2-(6-Chloro-4-(trifluoromethyl)pyridin-2-yl)ethan-1-amine (CAS 1165931-94-1)
- 2-(6-Chloro-4-(trifluoromethyl)pyridin-3-yl)ethan-1-amine (CAS 1256788-40-5)
- 4-Chloro-2-(propan-2-yl)-6-(trifluoromethyl)pyrimidine (CAS 126439-51-8)
- 2-(2-Chloro-5-(trifluoromethyl)pyridin-3-yl)ethan-1-amine (CAS 1360883-59-5)
Recommended Standards
- 1-[2-chloro-6-(trifluoromethyl)pyridin-3-yl]ethan-1-amine (CAS 944904-54-5)
- 1-Chloro-2-(methoxymethyl)-3-(trifluoromethyl)benzene (CAS 2379321-58-9)
- 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)ethan-1-amine (CAS 326809-08-9)
- 1-Chloro-3-(methoxymethyl)-5-(trifluoromethyl)benzene (CAS 2364584-72-3)
- 2-((5-(Trifluoromethyl)pyridin-2-yl)thio)ethan-1-amine hydrochloride (CAS 1208081-88-2)
- Etomidate Impurity 12 (CAS 36065-27-7)
- 4,5-Dimethyloxazolidin-2-one (CAS 58628-98-1)
- 4-Methyl-N-(propan-2-yl)benzene-1-sulfonamide (CAS 21230-07-9)
- 6-(Benzyloxy)-2-naphthoic acid (CAS 114804-77-2)
- (2,3-Dichlorophenyl)(2-methylpyridin-4-yl)methanone (CAS 1187169-70-5)
- (E)-N',3,5-Trimethyl-N-[3-(trifluoromethyl)phenyl]benzene-1-carboximidamide (CAS 339010-02-5)
- 1-Acetyl-4-(3-bromopropyl)piperazine (CAS 335621-30-2)
- 2,6-Dibromo-1-iodo-4-(trifluoromethyl)benzene (CAS 1428234-52-9)
- [2-31]-Semaglutide C (x TFA Salt) (CAS CATO-C4X-2226118)
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