Regorafenib Impurity 10 CAS 348-90-3
| CAS No. | 348-90-3 |
| Molecular Formula | C9H7ClF3NO |
| Molecular Weight | 237.61 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Regorafenib Impurity 10 (CAS 348-90-3) is a certified pharmaceutical impurity reference standard with the molecular formula C9H7ClF3NO and a molecular weight of 237.61 g/mol.
Regorafenib Impurity 10 (C9H7ClF3NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), Regorafenib Impurity 10 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H7ClF3NO |
| Molecular Weight | 237.61 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Regorafenib Standards
- Regorafenib Impurity 64 (CAS CATO-C4X-104764)
- Regorafenib Impurity 19 (CAS 350602-02-7)
- Regorafenib Impurity 50 (CAS CATO-C4X-104750)
- Regorafenib Impurity 35 (CAS CATO-C4X-104735)
- Regorafenib Impurity 39 (CAS CATO-C4X-104739)
- Regorafenib Impurity 42 (CAS CATO-C4X-104742)
- Regorafenib Impurity 44 (CAS CATO-C4X-104744)
- Regorafenib Impurity 47 (CAS CATO-C4X-104747)
Recommended Standards
- N-(4-Methoxyphenyl)trifluoroacetimidoyl Chloride (CAS 75999-66-5)
- 3-Hydroxy-2-nitrobenzenesulfonyl chloride (CAS 1261554-31-7)
- N-(4-chloro-2-(trifluoromethyl)phenyl)acetamide (CAS 344-53-6)
- 2-hydroxy-5-nitrobenzene-1-sulfonyl chloride (CAS 1261760-59-1)
- Osimertinib Impurity 93 (CAS CATO-C4X-204593)
- Cefaclor Impurity 64 (CAS CATO-C4X-127064)
- Anamorelin Impurity 14 (CAS CATO-C4X-285914)
- 2-Fluoro-5-(hex-1-yn-1-yl)benzonitrile (CAS 2234897-52-8)
- 1-Butoxy-3,5-dichlorobenzene (CAS 1094778-40-1)
- 6-Chloro-2-(pyridin-2-yl)-1h-1,3-benzodiazole (CAS 63053-15-6)
- 1-Chloro-4-(Ethylthio)benzene (CAS 5120-72-9)
- 5-Bromo-3-(trifluoromethyl)benzene-1,2-diamine (CAS 157026-19-2)
- 1-(1-Methyl-1h-imidazol-4-yl)cyclopropane-1-carboxylic acid (CAS 1427020-64-1)
- D-Ile12-Tirzepatide (CAS CATO-CPTD788921)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com