Ambrisentan Impurity 4 CAS 35144-22-0
| CAS No. | 35144-22-0 |
| Molecular Formula | C7H10N2O2S |
| Molecular Weight | 186.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Ambrisentan Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Ambrisentan Impurity 4 (CAS 35144-22-0) is a certified pharmaceutical impurity reference standard with the molecular formula C7H10N2O2S and a molecular weight of 186.23 g/mol.
Owing to an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Ambrisentan Impurity 4 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C7H10N2O2S |
| Molecular Weight | 186.23 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ambrisentan Standards
- Ambrisentan Impurity N1 (CAS 76527-25-8)
- Ambrisentan Impurity 7 (CAS CATO-C4X-12467)
- Ambrisentan Impurity 5 (CAS 178306-51-9)
- Ambrisentan Impurity 8 (CAS CATO-C4X-12468)
- Ambrisentan (R)-Hydroxy Acid Impurity (CAS 178306-49-5)
- Ambrisentan (S)-Hydroxy Acid Impurity (CAS 178306-52-0)
- Ambrisentan Hydroxyester Impurity (CAS 177036-78-1)
- Ambrisentan Impurity 1 (CAS 178306-47-3)
Recommended Standards
- p-Toluenesulfonyl Hydrazide (CAS 1576-35-8)
- Meloxicam Impurity 16 (CAS 39122-64-0)
- Benzyl methanesulfonate (CAS 55791-06-5)
- Pazopanib Impurity 19 (CAS 6973-09-7)
- Gimeracil Impurity 6 (CAS 529-19-1)
- Baxdrostat Impurity 30 (CAS 1428651-83-5)
- Lenvatinib Impurity 94 (CAS CATO-C4X-114094)
- (2s)-3-(4-Hydroxyphenyl)-2-(prop-2-enamido)propanoic acid (CAS 192705-88-7)
- 3-Methoxy-N-(4-phenylthiazol-2-yl)-2-naphthamide (CAS 312914-29-7)
- Diphenyl terephthalate (CAS 1539-04-4)
- 1-(3-Pentyl-4,5-dihydroisoxazol-5-yl)ethanone (CAS 87899-06-7)
- 2-Isobutyltetrahydro-4H-pyran-4-one (CAS 23659-44-1)
- 2-(Methylsulfonyl)cyclopentan-1-amine (CAS 1221723-17-6)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
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