Moxonidine EP Impurity A CAS 352457-35-3
| CAS No. | 352457-35-3 |
| Molecular Formula | C8H9Cl2N5 |
| Molecular Weight | 246.10 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Moxonidine EP Impurity A (CAS 352457-35-3) is a certified pharmaceutical impurity reference standard with the molecular formula C8H9Cl2N5 and a molecular weight of 246.10 g/mol.
Moxonidine EP Impurity A (C8H9Cl2N5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C8H9Cl2N5 |
| Molecular Weight | 246.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
Related Moxonidine Standards
Recommended Standards
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- Baclofen impurity 43 (CAS CATO-C4X-101243)
- Bromfenac Impurity 38 (CAS 241496-82-2)
- Lobeline impurity 20 (CAS 101113-68-2)
- Phorate Oxon (CAS 2600-69-3)
- Ethyl 2-amino-4-tert-butylthiophene-3-carboxylate (CAS 827614-39-1)
- Methyl 4-chloro-1-(2,4-dichlorobenzoyl)pyrrolidine-2-carboxylate (CAS 251310-38-0)
- 6-Methyl-2-oxo-2,3-dihydro-1h-1,3-benzodiazole-5-sulfonyl chloride (CAS 1023816-32-1)
- Pitavastatin Impurity 54 (CAS 1187966-95-5)
- Macitentan Impurity 6 (CAS CATO-C4X-11756)
- KALA Amphipathic Peptide (CAS 187987-64-0)
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