Perindopril EP Impurity H CAS 353777-64-7
| CAS No. | 353777-64-7 |
| Molecular Formula | C30H48N4O4 |
| Molecular Weight | 528.73 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 528.73 g/mol gives Perindopril EP Impurity H distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Perindopril EP Impurity H (CAS 353777-64-7), a pharmacopoeial impurity reference standard (molecular formula C30H48N4O4, MW 528.73 g/mol) used for the identification and quantification of trace impurities in APIs.
Perindopril EP Impurity H (C30H48N4O4) contains a steroid core, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Perindopril EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C30H48N4O4 |
| Molecular Weight | 528.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 4 |
Related Perindopril Standards
- Perindopril EP Impurity O (CAS CATO-C4X-125272)
- Perindopril Acyl-beta-D-Glucuronide (CAS 120398-66-5)
- Perindopril Benzyl Ester (CAS 122454-52-8)
- Perindopril EP Impurity G (CAS 353777-66-9)
- Perindopril Impurity 107 (CAS CATO-C4X-1252107)
- Perindopril Impurity 108 (CAS CATO-C4X-1252108)
- Perindopril Impurity 109 (CAS CATO-C4X-1252109)
- Perindopril Impurity 106 (CAS CATO-C4X-1252106)
Recommended Standards
- 3-Cyclohexyl-5-(5-(3-ethyl-4,5-diphenyloxazol-2(3H)-ylidene)pent-3-en-2-ylidene)-2-thioxothiazolidin-4-one (CAS 58090-15-6)
- Mianserin Impurity 119 (CAS CATO-C4X-1369119)
- Alisol C monoacetate (CAS 26575-93-9)
- (3β,20S)-20-Methyl-pregn-5-ene-3,21-diol 3-Acetate 21-Tosyl (CAS 120664-97-3)
- Selexipag Impurity 16 (CAS CATO-C4X-196116)
- Daclatasvir Impurity 26 (CAS 2226541-13-3)
- Levocarnitine Impurity N6 (CAS 16072-48-3)
- (R)-3-Phenylisobenzofuran-1(3H)-one (CAS 87481-14-9)
- 2,6,6-Trimethyl-1-cyclohexene-1-carbonitrile 2,6,6-Trimethylcyclohex-2-ene-1-ylcarbonitrile 57524-14-8 (CAS 57524-14-8)
- Tert-butyl 6-methyloctahydro-1H-pyrrolo[2,3-c]pyridine-1-carboxylate (CAS 1443980-54-8)
- 2-(Azepan-1-yl)-5-chlorothiazole-4-carboxylic acid (CAS 1403567-33-8)
- 3-Amino-1-cyclobutyl-2-methylpropan-1-ol (CAS 1491428-80-8)
- Tris(trimethylsilyl) Phosphite (CAS 1795-31-9)
- Liraglutide Impurity 6 TFA Salt (CAS CATO-C4X-19926)
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