Perindopril EP Impurity G CAS 353777-66-9
| CAS No. | 353777-66-9 |
| Molecular Formula | C24H37N3O5 |
| Molecular Weight | 447.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Perindopril EP Impurity G.
Perindopril EP Impurity G (CAS 353777-66-9) is a certified pharmaceutical impurity reference standard with the molecular formula C24H37N3O5 and a molecular weight of 447.57 g/mol.
The molecular framework of Perindopril EP Impurity G (C24H37N3O5) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Perindopril EP Impurity G meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C24H37N3O5 |
| Molecular Weight | 447.57 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 3 |
Related Perindopril Standards
- Perindopril Benzyl Ester (CAS 122454-52-8)
- Perindopril Impurity 107 (CAS CATO-C4X-1252107)
- Perindopril Impurity 108 (CAS CATO-C4X-1252108)
- Perindopril Impurity 106 (CAS CATO-C4X-1252106)
- Perindopril Impurity 71 (CAS CATO-C4X-125271)
- Perindopril Impurity 40 (CAS CATO-C4X-125240)
- Perindopril Impurity 115 (CAS CATO-C4X-1252115)
- Perindopril EP Impurity E (CAS 1356837-89-2)
Recommended Standards
- 2-(2H-Benzotriazol-2-yl)-4,6-bis(1-methyl-1-phenylethyl)phenol (CAS 70321-86-7)
- 1-(4-(2-(Benzyloxy)-4-fluorophenyl)-2,6-diisopropyl-5-(prop-1-en-1-yl)pyridin-3-yl)ethanol (CAS 503559-84-0)
- Selexipag Impurity 5 (CAS 2287345-22-4)
- N-((5-Acetamidoquinolin-8-yl)sulfonyl)dodecanamide (CAS 102107-36-8)
- Butenafine Impurity 4 (CAS 101827-53-6)
- Baclofen impurity 45 (CAS CATO-C4X-101245)
- Capecitabine Impurity 24 (CAS CATO-C4X-102424)
- N-(2,6-Dichlorobenzyl)piperidin-3-amine hydrochloride (CAS 1261230-61-8)
- 1-Isopropyl-N-((1-methyl-1H-pyrazol-5-yl)methyl)-1H-pyrazol-4-amine hydrochloride (CAS 1855948-04-7)
- 2-((3-Oxocyclohex-1-enyl)amino)benzoic acid (CAS 132600-13-6)
- 3-Bromoquinoline-6-sulfonyl chloride (CAS 1956381-95-5)
- 2,2'-(1,3-Dioxolane-2,2-diyl)diacetic acid (CAS 5694-91-7)
- 3-Fluoro-N,2-dimethylbenzamide (CAS 634924-03-1)
- Semaglutide impurity 71 (CAS CATO-C4X-222671)
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