Rivaroxaban Impurity 103 CAS 35475-03-7
| CAS No. | 35475-03-7 |
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Rivaroxaban Impurity 103 (CAS 35475-03-7, C6H5ClO2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Rivaroxaban Impurity 103 (C6H5ClO2S) is characterized by a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C6H5ClO2S |
| Molecular Weight | 176.62 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Rivaroxaban Standards
- Rivaroxaban Impurity 38 (CAS 29518-11-4)
- Rivaroxaban Impurity 53 (CAS 66357-41-3)
- Rivaroxaban CMTCA Impurity (CAS 97799-98-9)
- Rivaroxaban Impurity 137 (CAS 3140-73-6)
- Rivaroxaban Impurity 95 (CAS 4789-09-7)
- Rivaroxaban Impurity 84 (CAS 2524-67-6)
- Rivaroxaban Impurity 112 (CAS 90564-02-6)
- Rivaroxaban Impurity 74 (CAS 113471-08-2)
Recommended Standards
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