Posaconazole Impurity 43 CAS 357189-95-8
| CAS No. | 357189-95-8 |
| Molecular Formula | C37H40F2N8O6 |
| Molecular Weight | 730.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Posaconazole Impurity 43 (CAS 357189-95-8) is a certified pharmaceutical impurity reference standard with the molecular formula C37H40F2N8O6 and a molecular weight of 730.76 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, Posaconazole Impurity 43 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 730.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C37H40F2N8O6 |
| Molecular Weight | 730.76 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 21.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole Impurity 281 (CAS CATO-C4X-1208281)
- Posaconazole Impurity 169 (CAS 2069239-68-3)
- Posaconazole Impurity 50 (CAS 1902957-95-2)
- Posaconazole Impurity 155 (CAS CATO-C4X-1208155)
- Posaconazole impurity 233 (CAS CATO-C4X-1208233)
- Posaconazole Impurity 259 (CAS CATO-C4X-1208259)
- Posaconazole Impurity 64 (CAS CATO-C4X-120864)
- Posaconazole Formylurea Analogue (CAS CATO-C4X-1208192)
Recommended Standards
- (3S,6S)-N-((1H-1,2,3-Triazol-5-yl)methyl)-3-((2S,3S)-2-(2-(benzo[b]thiophen-3-yl)acetamido)-3-methylpentanamido)-4-oxo-1,2,3,4,6,7-hexahydroazepino[3,2,1-hi]indole-6-carboxamide (CAS 498555-58-1)
- Carvedilol Impurity 29 (CAS CATO-C4X-157429)
- Napipitant Impurity 2 (CAS CATO-C4X-34852)
- Carvedilol Impurity 30 (CAS CATO-C4X-157430)
- Riociguat Impurity 19 (CAS CATO-C4X-174919)
- Mirtazapine Impurity 30 (CAS CATO-C4X-151130)
- Sultamicillin EP Impurity A (CAS CATO-C4X-18861)
- 4,6-Dimethyl-1h-pyrazolo[3,4-b]pyridine-3-sulfonyl chloride (CAS 134310-07-9)
- 2,2,2-Trifluoro-1-(1-vinyl-1H-pyrrol-2-yl)ethanone (CAS 73415-87-9)
- Iodomethane-13C,d3 (Copper Wire Stabilized) (CAS 20710-47-8)
- (5-Chlorofuro[3,2-b]pyridin-2-yl)methanamine dihydrochloride (CAS 2680533-04-2)
- 1-(3,3,3-Trifluoropropyl)cyclopropane-1-carboxylic acid (CAS 1500189-48-9)
- α-Cyclodextrin, 2-hydroxypropyl ethers (CAS 128446-33-3)
- Neuropeptide Y, porcine (CAS 82785-45-3)
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