Posaconazole Impurity 50 CAS 1902957-95-2
| CAS No. | 1902957-95-2 |
| Molecular Formula | C37H42F2N8O6 |
| Molecular Weight | 732.78 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, Posaconazole Impurity 50 (CAS 1902957-95-2, C37H42F2N8O6) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Posaconazole Impurity 50 (C37H42F2N8O6) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 732.78 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Posaconazole Impurity 50 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C37H42F2N8O6 |
| Molecular Weight | 732.78 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 8 |
Related Posaconazole Standards
- Posaconazole Impurity 281 (CAS CATO-C4X-1208281)
- Posaconazole Impurity 43 (CAS 357189-95-8)
- Posaconazole Impurity 169 (CAS 2069239-68-3)
- Posaconazole Impurity 78 (CAS CATO-C4X-120878)
- Posaconazole Impurity 155 (CAS CATO-C4X-1208155)
- Posaconazole impurity 233 (CAS CATO-C4X-1208233)
- Posaconazole Impurity 259 (CAS CATO-C4X-1208259)
- Posaconazole Impurity 64 (CAS CATO-C4X-120864)
Recommended Standards
- 4,4''-Bis(bis(4-formylphenyl)amino)-[1,1':4',1''-terphenyl]-2',5'-dicarbaldehyde (CAS 2097132-15-3)
- 5'-[(Desloratadine)methyl] Rupatadine-d8 (CAS 1794669-33-2)
- Spiro[fluorene-9,9'-xanthene]-2,7-diylbis(diphenylphosphineoxide) (CAS 1346002-81-0)
- 8,8'-Bis(((3-fluoro-4-methylphenyl)imino)methyl)-5,5'-diisopropyl-3,3'-dimethyl-[2,2'-binaphthalene]-1,1',6,6',7,7'-hexaol (CAS 6945-73-9)
- Regadenoson Impurity 40 (CAS CATO-C4X-198540)
- Hydrochlorothiazide Impurity 18 (CAS 89813-56-9)
- Linaclotide impurity 38 (CAS CATO-C4X-210638)
- 3-(2,6-Difluorobenzyl)pyrrolidine (CAS 1337673-70-7)
- 6-Bromo-8-fluoro-2h-chromene-3-sulfonyl chloride (CAS 1235439-15-2)
- Rel-(2S,6S)-6-methylpiperidine-2-carboxylic acid (CAS 89115-89-9)
- Trimethyl(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)furan-3-yl)silane (CAS 1111096-50-4)
- [6-cyclopropyl-4-(methoxycarbonyl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid (CAS 1011396-63-6)
- 4-((5-(1H-Imidazol-1-yl)pentyl)oxy)-N-hexadecylaniline (CAS 88138-41-4)
- Liraglutide Impurity 25 (CAS CATO-C4X-199225)
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