Lidocaine Hydrochloride EP Impurity G(HCl) CAS 35891-87-3

Description

Compared with other compounds in its class, the molecular weight of 256.77 g/mol gives Lidocaine Hydrochloride EP Impurity G(HCl) distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

As a process- or degradation-related impurity, Lidocaine Hydrochloride EP Impurity G(HCl) (CAS 35891-87-3, C13H20N2OHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.

Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Lidocaine Hydrochloride EP Impurity G(HCl) is typically off-white to pale yellow low-melting solid. Its solid-state physicochemical attributes — including a molecular weight of 256.77 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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