5-Nitrothiophene-2-sulfonyl chloride CAS 36035-01-5
| CAS No. | 36035-01-5 |
| Molecular Formula | C4H2ClNO4S2 |
| Molecular Weight | 227.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 227.65 g/mol gives 5-Nitrothiophene-2-sulfonyl chloride distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Nitrothiophene-2-sulfonyl chloride (CAS 36035-01-5) is a high-purity analytical reference standard with the molecular formula C4H2ClNO4S2 and a molecular weight of 227.65 g/mol.
5-Nitrothiophene-2-sulfonyl chloride (C4H2ClNO4S2) contains a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClNO4S2 |
| Molecular Weight | 227.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Nitrothiophene Standards
- 2-nitrothiophene-3-sulfonyl chloride (CAS 1421602-28-9)
- 4-nitrothiophene-2-sulfonyl chloride (CAS 40358-04-1)
- 5-Nitrothiophene-3-sulfonyl chloride (CAS 69824-57-3)
- 5-Methyl-4-nitrothiophene-2-sulfonamide (CAS 905839-54-5)
- 3-Nitrothiophene-2,5-dicarboxylic acid (CAS 1437794-39-2)
- 2-Nitrothiophene-3,4-dicarboxylic acid (CAS 932032-15-0)
- 5-methyl-2-nitrothiophene-3-sulfonyl chloride (CAS 1909348-24-8)
- 5-Methyl-4-nitrothiophene-2-sulfonyl chloride (CAS 61714-77-0)
Recommended Standards
- 5-Chloro-2-(pyrrolidin-1-yl)pyrimidine-4-carboxylic acid (CAS 327064-06-2)
- 6-Chloro-3,4-dihydro-2H-1,4-benzoxazine-2-carbohydrazide (CAS 866134-48-7)
- 4-Chloro-6-morpholinopyrimidine-5-carbaldehyde (CAS 54503-94-5)
- 9-((2-Chloroethoxy)methyl)-9H-purin-6-amine (CAS 56004-32-1)
- 3-Chloro-2-methyl-N-(1-methylpiperidin-3-yl)pyrazolo[1,5-a]quinazolin-5-amine (CAS 1210214-66-6)
- ethyl-3-aminocrotonate (CAS 3222-57-9)
- [Tyr0] Corticotropin Releasing Factor, human, rat (CAS 100915-92-2)
- 3-ethyl-3-(4-methylphenyl)oxolane-2,5-dione (CAS 1094328-65-0)
- N-[(2-Methylphenyl)methyl]piperidine-2-carboxamide (CAS 189069-85-0)
- 4-(3-Chloro-5-fluorophenyl)benzaldehyde (CAS 1381944-68-8)
- (2-(Bromomethyl)-3-methylbutyl)cyclopentane (CAS 1496207-63-6)
- 1-Methyl-4-(trifluoromethyl)piperidin-4-amine (CAS 1339590-57-6)
- N-Cbz-D-serine Methyl Ester (CAS 93204-36-5)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
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