5-Nitrothiophene-3-sulfonyl chloride CAS 69824-57-3
| CAS No. | 69824-57-3 |
| Molecular Formula | C4H2ClNO4S2 |
| Molecular Weight | 227.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Nitrothiophene-3-sulfonyl chloride.
CATO supplies 5-Nitrothiophene-3-sulfonyl chloride (CAS 69824-57-3), a certified reference material (molecular formula C4H2ClNO4S2, MW 227.65 g/mol) for analytical method development and quality control.
Owing to a carbohydrate-derived structure, an amide group, a sulfone group, chlorine substitution, 5-Nitrothiophene-3-sulfonyl chloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 227.65 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H2ClNO4S2 |
| Molecular Weight | 227.65 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1976 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 2 |
Related Nitrothiophene Standards
- 2-nitrothiophene-3-sulfonyl chloride (CAS 1421602-28-9)
- 4-nitrothiophene-2-sulfonyl chloride (CAS 40358-04-1)
- 5-Nitrothiophene-2-sulfonyl chloride (CAS 36035-01-5)
- 5-Methyl-4-nitrothiophene-2-sulfonamide (CAS 905839-54-5)
- 3-Nitrothiophene-2,5-dicarboxylic acid (CAS 1437794-39-2)
- 2-Nitrothiophene-3,4-dicarboxylic acid (CAS 932032-15-0)
- 5-methyl-2-nitrothiophene-3-sulfonyl chloride (CAS 1909348-24-8)
- 5-Methyl-4-nitrothiophene-2-sulfonyl chloride (CAS 61714-77-0)
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