Flunarizine Impurity 25 CAS 365-22-0
| CAS No. | 365-22-0 |
| Molecular Formula | C13H11FO |
| Molecular Weight | 202.22 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Flunarizine Impurity 25 (CAS 365-22-0) is a certified pharmaceutical impurity reference standard with the molecular formula C13H11FO and a molecular weight of 202.22 g/mol.
The molecular framework of Flunarizine Impurity 25 (C13H11FO) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Flunarizine Impurity 25 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H11FO |
| Molecular Weight | 202.22 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Flunarizine Standards
- Flunarizine Impurity 59 (CAS 114312-65-1)
- Flunarizine Impurity 9 (CAS 87179-40-6)
- Flunarizine impurity 47 (CAS 148728-47-6)
- Flunarizine Impurity 18 (CAS 6416-39-3)
- Flunarizine impurity 43 (CAS 1133842-25-7)
- Flunarizine Impurity 10 (CAS 345-92-6)
- Flunarizine Impurity 8 (CAS 365-24-2)
- Flunarizine Impurity 17 (CAS 17730-78-8)
Recommended Standards
- 3-(4-FLUORO-PHENYL)-3-OXO-PROPIONIC ACID METHYL ESTER 63131-29-3 AS06137 METHYL 4'-FLUOROBENZOYLACETATE METHYL P-FLUOROBENZOYL ACETATE Methyl 4-fluorobenzoylacetate OTAVA-BB 1785335 (CAS 63131-29-3)
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- N-(2,2-dimethylcyclopentyl)thietan-3-amine (CAS 1862888-44-5)
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- tert-Butyl ((1r,4r)-4-(2-bromoethyl)cyclohexyl)carbamate (CAS 1062468-06-7)
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