Linezolid Impurity 13 CAS 369-34-6
| CAS No. | 369-34-6 |
| Molecular Formula | C6H3F2NO2 |
| Molecular Weight | 159.09 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Linezolid Impurity 13 (CAS 369-34-6, C6H3F2NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system, Linezolid Impurity 13 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 159.09 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C6H3F2NO2 |
| Molecular Weight | 159.09 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Linezolid Standards
- Linezolid Impurity 65 (CAS CATO-C4X-107365)
- Linezolid Impurity 14 (CAS 1445-69-8)
- Linezolid Impurity 39 (CAS 39608-52-1)
- Linezolid Impurity 77 (CAS 3920-11-4)
- Linezolid Impurity 40 (CAS 224323-47-1)
- Linezolid Impurity 97 (CAS 384344-17-6)
- Linezolid Impurity 81 (CAS 38711-20-5)
- Linezolid Impurity 96 (CAS 152139-76-9)
Recommended Standards
- 2,3-Difluoronitrobenzene (CAS 6921-22-8)
- 2,4-Difluoro-1-nitrobenzene (CAS 446-35-5)
- 3,6-Difluoro pyridine-2-carboxylic acid 3,6-Difluoro-2-pyridinecarboxylic acid;3,6-difluoropicolinic acid 851386-45-3 A26073 (CAS 851386-45-3)
- 2,6-difluoronitrobenzene (CAS 19064-24-5)
- Terazosin EP Impurity M (CAS 31350-27-3)
- Lifitegrast Impurity 107 (CAS CATO-C4X-2409107)
- Mesalazine Impurity 28 (CAS 40038-46-8)
- METHYL(2R,3S)-N-BENZOYL-3-PHENYLISOSERINE (CAS 132074-01-2)
- Verapamil EP Impurity N HCl (CAS 2086274-75-9 (free base))
- Isopropyl 4-sulfamoylbenzoate (CAS 91013-50-2)
- Cevimeline (CAS 107233-08-9)
- 3-[(furan-2-ylmethyl)sulfanyl]prop-2-enoic acid (CAS 1384433-83-3)
- 1-Benzoyl-2-methylpiperidin-4-one (CAS 13729-76-5)
- Peptide Impurity 24 (CAS CATO-CPTD788824)
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