Chlorquinaldol impurity 3 CAS 37026-23-6
| CAS No. | 37026-23-6 |
| Molecular Formula | C10H8ClNO |
| Molecular Weight | 193.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Chlorquinaldol impurity 3 (CAS 37026-23-6) is a certified pharmaceutical impurity reference standard with the molecular formula C10H8ClNO and a molecular weight of 193.63 g/mol.
The molecular framework of Chlorquinaldol impurity 3 (C10H8ClNO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Chlorquinaldol impurity 3 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClNO |
| Molecular Weight | 193.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chlorquinaldol Standards
Recommended Standards
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- Sitagliptin Impurity 35 (CAS 218609-00-1)
- Amlodipine Impurity 60 (CAS 949155-13-9)
- Lotilaner Impurity 29 (CAS 2226274-70-8)
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- 3-[2-(4-Propylphenoxy)ethyl]piperidinehydrochloride (CAS 1219972-12-9)
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- 1-(3-Bromophenyl)-4-(5,5-dimethyl-1,3-dioxan-2-yl)butan-1-one (CAS 898785-72-3)
- (1s,4s,6r)-5-(Tert-butoxycarbonyl)-7,7-difluoro-2-oxa-5-azabicyclo[4.1.0]heptane-4-carboxylic acid (CAS 1955473-86-5)
- Gastric Inhibitory Polypeptide (6-30) amide (human) (CAS 1139691-72-7)
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