Letrozole Impurity 28 CAS 46209-39-6
| CAS No. | 46209-39-6 |
| Molecular Formula | C9H8ClN3 |
| Molecular Weight | 193.63 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Letrozole Impurity 28.
Letrozole Impurity 28 (CAS 46209-39-6) is a certified pharmaceutical impurity reference standard with the molecular formula C9H8ClN3 and a molecular weight of 193.63 g/mol.
Letrozole Impurity 28 (C9H8ClN3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Letrozole Impurity 28 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C9H8ClN3 |
| Molecular Weight | 193.63 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1970 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Letrozole Standards
- Letrozole Impurity 39 (CAS 28188-41-2)
- Letrozole Impurity 15 (CAS 74231-65-5)
- Letrozole Impurity 24 (CAS CATO-C4X-182924)
- Letrozole Impurity 33 (CAS 1461654-89-6)
- Letrozole Impurity 17 (CAS 112809-27-5)
- Letrozole Impurity 22 (CAS 876728-37-9)
- Letrozole Impurity 23 (CAS 876316-41-5)
- Letrozole Impurity 4 (CAS 112809-25-3)
Recommended Standards
- Ketoprofen Impurity 22 (CAS 42872-29-7)
- Chlorquinaldol impurity 3 (CAS 37026-23-6)
- Ziprasidone Impurity 60 (CAS 2166666-15-3)
- (4-Chloro-2-ethoxythiazol-5-yl)methanol (CAS 1211505-63-3)
- Crisaborole Impurity 8 (CAS CATO-C4X-20218)
- Cinitapride Impurity 30 (CAS CATO-C4X-290830)
- Loperamide EP Impurity F (CAS 106900-12-3)
- Ethyl 2,4-diphenyl-6-(piperidin-1-yl)pyrimidine-5-carboxylate (CAS 823794-32-7)
- tert-Butyl (5-(hydroxymethyl)-2,2-dimethyl-1,3-dioxan-5-yl)carbamate (CAS 364631-72-1)
- Oxirane, 2-methyl-, polymer with oxirane, mono-2-propenoate (CAS 9041-78-5)
- (3S,4R)-1-Benzyl-3-(2-chloroethyl)-4-phenylazetidin-2-one (CAS 1378029-49-2)
- 2,3-Dibromo-4,5-dimethoxybenzonitrile (CAS 330462-55-0)
- 1-[2,6-Dichloro-4-(trifluoromethyl)phenyl]-3,4-dimethyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 186042-18-2)
- 59880-97-6 Chemotactic peptide F-Met-Leu-Phe L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)- N-Formyl-L-methionyl-L-leucyl-L-phenylalanine N-Formyl-Met-Leu-Phe N-Formylmethionine leucyl-phenylalanine fMLF fMLP (misnomer but widely used) (CAS 59880-97-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com