Lotilaner Impurity 29 CAS 2226274-70-8
| CAS No. | 2226274-70-8 |
| Molecular Formula | C8H2BrCl2F3O |
| Molecular Weight | 321.91 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Lotilaner Impurity 29.
Lotilaner Impurity 29 (CAS 2226274-70-8) is a certified pharmaceutical impurity reference standard with the molecular formula C8H2BrCl2F3O and a molecular weight of 321.91 g/mol.
Owing to a hydroxyl group, an ether linkage, fluorine/chlorine/bromine substitution, an aromatic ring system, Lotilaner Impurity 29 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 321.91 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Lotilaner Impurity 29 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H2BrCl2F3O |
| Molecular Weight | 321.91 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1998 |
| Halogen Content | F/Cl/Br-containing |
Related Lotilaner Standards
- Lotilaner Impurity 7 (CAS CATO-C4X-32567)
- Lotilaner Impurity 20 (CAS CATO-C4X-325620)
- Lotilaner Impurity 23 (CAS CATO-C4X-325623)
- Lotilaner Impurity 4 (CAS CATO-C4X-32564)
- Lotilaner Impurity 15 (CAS CATO-C4X-325615)
- Lotilaner Impurity 21 (CAS CATO-C4X-325621)
- Lotilaner Impurity 14 (CAS CATO-C4X-325614)
- Lotilaner Impurity 8 (CAS CATO-C4X-32568)
Recommended Standards
- 3-Bromo-2-chloro-5-(trifluoromethyl)benzoyl chloride (CAS 2169633-17-2)
- (R)-2,4-Diiodo-3-methylbut-1-ene (CAS 481048-22-0)
- 3,5-Dibromo-2-fluorobenzotrifluoride (CAS 1806353-73-0)
- 1,1-Bis(iodomethyl)cyclopropane (CAS 83321-23-7)
- Amiodarone Impurity 33 (CAS CATO-C4X-142533)
- Fosaprepitant Impurity 53 (CAS 1254261-32-9)
- Faropenem Impurity 71 (CAS CATO-C4X-128971)
- 3,4-Difluoro-2-methylbenzamide (CAS 1806277-70-2)
- 1185301-61-4 4-(4-Methyl-4H-[1,2,4]triazol-3-yl)-piperidinedihydrochloride (CAS 1185301-61-4)
- 3-Methyl-N-((3-methyl-1h-pyrazol-4-yl)methyl)butan-2-amine (CAS 1156894-33-5)
- Zinc 2,11,20,29-tetra-tert-butyl-2,3-naphthalocyanine (CAS 39049-43-9)
- 2-(2-(Methylamino)ethoxy)acetic acid (CAS 98137-58-7)
- H-D-Dap(Boc)-OH (CAS 1208162-98-4)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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