Avanafil Impurity 78 CAS 372117-76-5
| CAS No. | 372117-76-5 |
| Molecular Formula | C16H18ClN3O5S |
| Molecular Weight | 399.85 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, Avanafil Impurity 78 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 399.85 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
CATO supplies Avanafil Impurity 78 (CAS 372117-76-5), a pharmacopoeial impurity reference standard (molecular formula C16H18ClN3O5S, MW 399.85 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Avanafil Impurity 78 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H18ClN3O5S |
| Molecular Weight | 399.85 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Avanafil Standards
- Avanafil Impurity 4 (CAS 1452128-53-8)
- Avanafil Impurity 115 (CAS CATO-C4X-1118115)
- Avanafil Impurity 117 (CAS CATO-C4X-1118117)
- Avanafil Impurity 121 (CAS CATO-C4X-1118121)
- Avanafil Impurity 134 (CAS CATO-C4X-1118134)
- Avanafil Impurity 22 (CAS 2250242-48-7)
- Avanafil Impurity 44 (CAS CATO-C4X-111844)
- Avanafil Impurity 45 (CAS CATO-C4X-111845)
Recommended Standards
- N'-((5-(4-Chlorobenzyl)-6-oxo-2-thioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methylene)isonicotinohydrazide (CAS 31349-14-1)
- (2Z)-3-[2-(4-Chlorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]-2-(3-methoxyphenyl)prop-2-enenitrile (CAS 1164540-00-4)
- Methyl 2-amino-4-(2-chlorophenyl)-5-oxo-4H,5H-thiochromeno[4,3-b]pyran-3-carboxylate (CAS 939894-13-0)
- (2Z)-3-[2-(4-Chlorophenyl)-8-methylimidazo[1,2-a]pyridin-3-yl]-2-(4-methoxyphenyl)prop-2-enenitrile (CAS 1164546-48-8)
- Opicapone Impurity 74 (CAS CATO-C4X-240474)
- Lercanidipine Impurity 33 (CAS 927-73-1)
- Mianserin Impurity 59 (CAS CATO-C4X-136959)
- 1-(4-(Bromomethyl)phenyl)-1h-1,2,4-triazole hydrobromide (CAS 1185064-09-8)
- Finerenone Impurity 187 (CAS CATO-C4X-2880187)
- 2-(2-Benzothiazolyl)-3,5-diphenyltetrazolium Bromide (CAS 55699-64-4)
- Janagliflozin impurity 3 (CAS CATO-C4X-30323)
- (Tyr?)-C-Type Natriuretic Peptide (32-53) (human, porcine, rat) (CAS 142878-79-3)
- (4-(4-Chlorophenyl)thiazol-2-yl)methanol (CAS 287198-05-4)
- Tirzepatide Impurity 34 (CAS CATO-C4X-324034)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com