4-Chloro-6-(piperazin-1-yl)pyrimidine CAS 373356-50-4
| CAS No. | 373356-50-4 |
| Molecular Formula | C8H11ClN4 |
| Molecular Weight | 198.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C8H11ClN4, 4-Chloro-6-(piperazin-1-yl)pyrimidine contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 198.65 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
4-Chloro-6-(piperazin-1-yl)pyrimidine (CAS 373356-50-4) is a high-purity analytical reference standard with the molecular formula C8H11ClN4 and a molecular weight of 198.65 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H11ClN4 |
| Molecular Weight | 198.65 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chloro Standards
- 6-Chloro-4-(isopropylamino)nicotinaldehyde (CAS 1012880-02-2)
- 2-Chloro-6-(cyclopentyloxy)pyrazine (CAS 1016697-18-9)
- 3-Chloro-5-(methylsulfonyl)-1,2,4-thiadiazole (CAS 10191-91-0)
- 5-Chloro-6-methyl-3-(pyrrolidin-1-yl)-1,2,4-triazine (CAS 1023818-03-2)
- Methyl 2-(5-chloro-2-methylphenyl)acetate (CAS 1076191-96-2)
- Methyl (2-chloro-6-methylphenyl)acetate (CAS 1076192-08-9)
- 3-(4-Chloro-3-methylphenyl)propanoic acid (CAS 1086386-05-1)
- 2-Chloro-N-ethyl-N-methylnicotinamide (CAS 112006-59-4)
Recommended Standards
- 4-Chloro-6-(cyclopentyloxy)pyrimidine (CAS 405931-42-2)
- 4-chloro-6-(pyrrolidin-1-yl)pyrimidin-2-amine (CAS 263276-45-5)
- 4-chloro-3-propylbenzoic acid (CAS 42044-91-7)
- 4-Chloro-6-(pyrrolidin-1-yl)pyrimidin-5-amine (CAS 626217-76-3)
- Laminaritriose (CAS 3256-04-0)
- 2-Amino-4-methoxy-6-(trifluoromethyl)pyridine (CAS 1227597-11-6)
- Ethyl 2-(2-amino-4-chlorophenoxy)butanoate (CAS 1370599-87-3)
- Lenvatinib Impurity 27 (CAS 2868-37-3)
- 1-(4-Fluorophenyl)-1H-pyrrole (CAS 81329-31-9)
- N-(7-Bromoisoquinolin-3-yl)cyclopropanecarboxamide (CAS 1382846-24-3)
- (2R,3R,4R,5R)-2-(4-amino-2-oxo-1,3,5-triazin-1(2H)-yl)-5-((benzoyloxy)methyl)tetrahydrofuran-3,4-diyl dibenzoate (CAS 28998-36-9)
- Ethyl 5-(2-chlorophenyl)-1,3,4-thiadiazole-2-carboxylate (CAS 1993310-55-6)
- 1-(Furan-2-ylmethyl)-1H-pyrrole-3-carbaldehyde (CAS 59303-01-4)
- Endo-Pro36-Tirzepatide (CAS CATO-CPTD788688)
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