3,3-Difluoro-4-methyl-piperidine CAS 374822-46-5
| CAS No. | 374822-46-5 |
| Molecular Formula | C6H11F2N |
| Molecular Weight | 135.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 3,3-Difluoro-4-methyl-piperidine is closely related to fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
3,3-Difluoro-4-methyl-piperidine (CAS 374822-46-5) is a high-purity analytical reference standard with the molecular formula C6H11F2N and a molecular weight of 135.16 g/mol.
Structurally, 3,3-Difluoro-4-methyl-piperidine (C6H11F2N) contains fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 1.0, corresponding to approximately 1 ring(s) or double-bond equivalent(s). With a molecular weight of 135.16 g/mol, it falls into the low-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H11F2N |
| Molecular Weight | 135.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Difluoro Standards
- 4,4-Difluoro-1-methylpiperidine (CAS 1186194-60-4)
- 4,4-Difluoro-2-methylpiperidine (CAS 1234616-37-5)
- 4,4-Difluoro-3-methylpiperidine (CAS 1434248-01-7)
- (3,3-Difluoro-1-methyl-cyclobutyl)methanamine (CAS 1438241-16-7)
- 5,5-Difluoro-2-methylpiperidine (CAS 1558372-10-3)
- (R)-4,4-Difluoro-2-methylpiperidine (CAS 1670259-99-0)
- 3,3-Difluoro-4,4-dimethylpyrrolidine (CAS 1781338-77-9)
- 3,4-Difluoro-4-methylpiperidine (CAS 1823252-89-6)
Recommended Standards
- 3,3-Bis(fluoromethyl)cyclobutan-1-amine (CAS 2169136-20-1)
- 3,3-Difluorocyclohexan-1-amine (CAS 921753-34-6)
- 3-(Methylamino)benzaldehyde (CAS 339062-76-9)
- 3,4-dihydro-2H-benzo[b][1,4]oxazine (CAS 5735-53-5)
- Methyl 4-methyloctanoate (CAS 15870-07-2)
- 5-Chloro-2-fluoroiodobenzene (CAS 116272-42-5)
- 2-Benzyl-7-methoxy-2H-pyrazolo[3,4-c]pyridine (CAS 918882-23-2)
- methyl (2S,3R)-3-hydroxypyrrolidine-2-carboxylate hydrochloride (CAS 757961-41-4)
- 1-(3-Fluoro-5-hydroxyphenyl)ethanone (CAS 1214333-95-5)
- (3S,4R,5S)-Butyl 3,4,5,6-tetrahydroxy-2-oxohexanoate (CAS 98055-99-3)
- 4,5-Dimethylthiophene-2-sulfonamide (CAS 140646-53-3)
- 2-Fluoro-6-(1H-imidazol-2-yl)pyridine (CAS 438564-53-5)
- Tris(ethylthio)methane (CAS 6267-24-9)
- Semaglutide impurity 95 (CAS CATO-C4X-222695)
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