(R)-1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol CAS 376347-10-3
| CAS No. | 376347-10-3 |
| Molecular Formula | C8H6ClF3O |
| Molecular Weight | 210.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (R)-1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol.
(R)-1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol (CAS 376347-10-3) is a high-purity analytical reference standard with the molecular formula C8H6ClF3O and a molecular weight of 210.58 g/mol.
(R)-1-(3-chlorophenyl)-2,2,2-trifluoroethan-1-ol (C8H6ClF3O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6ClF3O |
| Molecular Weight | 210.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related R Standards
- 1-(2-Chlorophenyl)-2,2,2-trifluoroethanol (CAS 251352-64-4)
- 1-(3-Chlorophenyl)-2,2,2-trifluoroethanol (CAS 81577-11-9)
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- (E)-4-(3-chlorophenyl)-2-oxobut-3-enoic acid (CAS 1244025-00-0)
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- 2-Formyl-4,5,6,7-tetrahydrobenzofuran-3-carbonitrile (CAS 290820-97-2)
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- 1-(4-Nitrophenyl)-2-(triphenylphosphoranylidene)ethanone (CAS 1439-43-6)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
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